ID   KANL3_DANRE             Reviewed;         835 AA.
AC   Q499B3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=KAT8 regulatory NSL complex subunit 3;
DE   AltName: Full=NSL complex protein NSL3;
DE   AltName: Full=Non-specific lethal 3 homolog;
GN   Name=kansl3; Synonyms=nsl3; ORFNames=zgc:109953;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the NSL complex it is involved in acetylation of
CC       nucleosomal histone H4 on several lysine residues and therefore may be
CC       involved in the regulation of transcription. {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of complexes involved in histone
CC       modification such as the NSL complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC099996; AAH99996.1; -; mRNA.
DR   RefSeq; NP_001029348.1; NM_001034176.1.
DR   AlphaFoldDB; Q499B3; -.
DR   SMR; Q499B3; -.
DR   STRING; 7955.ENSDARP00000060632; -.
DR   ESTHER; danre-kanl3; NLS3-Tex30.
DR   PaxDb; Q499B3; -.
DR   PRIDE; Q499B3; -.
DR   Ensembl; ENSDART00000060633; ENSDARP00000060632; ENSDARG00000029556.
DR   GeneID; 555951; -.
DR   KEGG; dre:555951; -.
DR   CTD; 55683; -.
DR   ZFIN; ZDB-GENE-050809-132; kansl3.
DR   eggNOG; KOG3253; Eukaryota.
DR   GeneTree; ENSGT00390000007636; -.
DR   InParanoid; Q499B3; -.
DR   PhylomeDB; Q499B3; -.
DR   TreeFam; TF323466; -.
DR   PRO; PR:Q499B3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000029556; Expressed in testis and 27 other tissues.
DR   ExpressionAtlas; Q499B3; baseline and differential.
DR   GO; GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0044545; C:NSL complex; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
DR   GO; GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
DR   GO; GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR026555; NSL3/Tex30.
DR   PANTHER; PTHR13136; PTHR13136; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Nucleus; Reference proteome.
FT   CHAIN           1..835
FT                   /note="KAT8 regulatory NSL complex subunit 3"
FT                   /id="PRO_0000287140"
FT   REGION          474..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..772
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          813..835
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..503
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..537
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        813..829
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   835 AA;  89595 MW;  A67585D12C266110 CRC64;
     MFRPGGERDF QTSARRMGTS LLFQLSVHER ELDLVFLDHS YAKPWNAHPD ASSARPTRML
     FVTPRRQPEA SGDSDMSIDV ETVTPTPMPL YDNQKARSVM NECDRHVLFA RTVADGPPPP
     DDWEEHINKT GWSLAQNKLF NKVLKALQAE RLGRLANDGA CNEPVLRRIA VDKCARKVRH
     ALSSVSWDIK LTHWLHNTLL ESLSLAMLAA YLDVLQTLKS KVPSLIDRML LSSSVKTGAA
     GAEALSLLLK RPWDPAVGVL SHNKPSKLPG SPLILIAPSG PTNPAFPTSR RMRFWQSQLS
     CLGKVIPINV HVGSGANVGI TQCLEHMIGT VRGKVIEVHS HFPHKPIILV GWNVGSLMAC
     HVSLMEYMTA VVCLGFPLQT ISGPRGDVDD PLLDMKTPVL FVVGQNALQC SPENMEEFRE
     KIRADNSLVV VGGADDSLRI NSTKMKTEGL TQTMVDRCIQ DEIVDFLTGV LTRSESHGHG
     SGETRDLDAE KKKPRRELPF DLDRSRPSSP AVRDMSSVCS SPTASPKPKT VGLSPAQKSS
     LITATQLLKT HMQRSGTVLT HKQAQAQFAA FMKHNMLVRK SIPPGSPSCL FVPVPSEQVE
     GLERDDMRVH LKRRQTPSPT PTKASKRAKI KVTIVSHGDA AGNTPGSTAQ EVGLSGKPLG
     LTVGQTTVSG AKELSELLSA QRSGGLAEVS GALASSEGSF HSLQGSVISR SSSPVQAAGT
     AQAPSASSLL QGLSLSLQEI NTKSPGVPST TQVSGGKPQG QGQVLSSLSP GSGTLVRAVP
     MVSTGSGMTK TTAIHQLLTN GGLAKLANSL PGLAHVSSQS SGTSSTPRSK QRRPR