KANL3_RAT
ID KANL3_RAT Reviewed; 877 AA.
AC Q3KR73;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=KAT8 regulatory NSL complex subunit 3;
DE AltName: Full=NSL complex protein NSL3;
DE AltName: Full=Non-specific lethal 3 homolog;
GN Name=Kansl3; Synonyms=Nsl3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: As part of the NSL complex it is involved in acetylation of
CC nucleosomal histone H4 on several lysine residues and therefore may be
CC involved in the regulation of transcription. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NSL complex at least composed of MOF/KAT8,
CC KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BC105865; AAI05866.1; -; mRNA.
DR RefSeq; NP_001030007.1; NM_001034835.1.
DR AlphaFoldDB; Q3KR73; -.
DR SMR; Q3KR73; -.
DR STRING; 10116.ENSRNOP00000020955; -.
DR ESTHER; rat-Kansl3; NLS3-Tex30.
DR iPTMnet; Q3KR73; -.
DR PhosphoSitePlus; Q3KR73; -.
DR PaxDb; Q3KR73; -.
DR PRIDE; Q3KR73; -.
DR GeneID; 316328; -.
DR KEGG; rno:316328; -.
DR UCSC; RGD:1309220; rat.
DR CTD; 55683; -.
DR RGD; 1309220; Kansl3.
DR VEuPathDB; HostDB:ENSRNOG00000015417; -.
DR eggNOG; KOG3253; Eukaryota.
DR InParanoid; Q3KR73; -.
DR Reactome; R-RNO-3214847; HATs acetylate histones.
DR PRO; PR:Q3KR73; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000015417; Expressed in testis and 20 other tissues.
DR ExpressionAtlas; Q3KR73; baseline and differential.
DR Genevisible; Q3KR73; RN.
DR GO; GO:0000123; C:histone acetyltransferase complex; ISS:UniProtKB.
DR GO; GO:0044545; C:NSL complex; ISO:RGD.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
DR GO; GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
DR GO; GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
DR GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:1900095; P:regulation of dosage compensation by inactivation of X chromosome; ISO:RGD.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR026555; NSL3/Tex30.
DR PANTHER; PTHR13136; PTHR13136; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Chromatin regulator; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..877
FT /note="KAT8 regulatory NSL complex subunit 3"
FT /id="PRO_0000287139"
FT REGION 478..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 523
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P2N6"
FT MOD_RES 536
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2RSY1"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P2N6"
FT MOD_RES 746
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P2N6"
SQ SEQUENCE 877 AA; 93035 MW; E7765693598FA63B CRC64;
MAHRGGERDF QTSARRMGTS LLFQLSVHER ELDLVFLDHS YAKPWSAHPD ASSARPTRML
FVTPRRQQEN TIESDVPIDV ETVTATPAPL YDNQKARSVM NECERHVIFA RTDADAPPPP
EDWEEHVNRT GWTVAQNKLF NKILKALQSD RLARLANEGA CNEPVLRRVA VDKCARRVRQ
ALASVSWDTK LIQWLHTTLV ETLSLPMLAA YLDALQTLKG KIPTLIDRML VSSNTKTGAA
GAEALSLLLK RPWDPAVGVL SHNKPSKLPG SPLILIASSG PSSSVFPASR RHRFWQSQLS
CLGKVIPVAT HLLNNGSGVG VLQCLEHMTG AVRSKVLEIH SHFPHKPIIL IGWSTGALVA
CHVSVMEYVT AVVCLGFPLL TVDGPRGDVD DPLLDMKTPV LFVIGQNSLQ CHPEAMEDFR
EKIRAENSLV VVGGADDNLR ISKAKKKSEG LTQSMVDRCI QDEIVDFLTG VLTRAEGHVG
SEPRDQDAEK KKKPRDVARR DLAFEIPERG SRPASPAARL PTSPSGSEDL SSVSSSPTSS
PKTKGTTVTS AQKSSQIGTS QLLRRHVQRT DAVLTHRQAQ VPISSEPVEE VEKEELRVQL
KRHHPSSPLP GAKPSKRPKI KVSLISQGDT VGGPCTLSQG GTPEAAGGKP ITMTLGASAG
AKELTGLLTT AKSSSSEGGV TASAAPSVAS SNATPNAIHT LQSRLVATSP GSSLPGAASA
SSLLQGLSFS LQDISSKTTG LPGSPSPGPA PQATSVKLPT PMQSLGAITT GTSTIVRTIP
VATTLSSLAA TPGGKPTAIH QLLTNGGLAK LASSLPGLAQ ISNQASGLKV PTTITLTLRG
QPSRITTLSP MGSGAAASEE PNSQMLPSSS QRLPPAP
