ID   KAP1_CRIFA              Reviewed;         151 AA.
AC   O61016;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Kinetoplast-associated protein 1;
DE   AltName: Full=Histone H1-like protein p21;
DE   Flags: Precursor;
GN   Name=KAP4;
OS   Crithidia fasciculata.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Crithidia.
OX   NCBI_TaxID=5656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=C1;
RX   PubMed=9719509; DOI=10.1016/s0166-6851(98)00048-6;
RA   Hines J.C., Ray D.S.;
RT   "The Crithidia fasciculata KAP1 gene encodes a highly basic protein
RT   associated with kinetoplast DNA.";
RL   Mol. Biochem. Parasitol. 94:41-52(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 10-22, DNA-BINDING, AND SUBCELLULAR LOCATION.
RX   PubMed=8446592; DOI=10.1073/pnas.90.5.1786;
RA   Xu C., Ray D.S.;
RT   "Isolation of proteins associated with kinetoplast DNA networks in vivo.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:1786-1789(1993).
CC   -!- FUNCTION: Histone H1-like DNA-binding protein involved in the
CC       organization and segregation of kinetoplast DNA (kDNA). The
CC       mitochondrial DNA of kinetoplastid protozoa consists of about 5,000
CC       minicircles and 20 to 30 maxicircles. These circular DNAs are held
CC       together by catenation into a highly organized compact disk structure
CC       referred to as a kinetoplast DNA (kDNA) network. Binds preferentially
CC       to a specific fragment of minicircle DNA and is able to compact kDNA
CC       networks through DNA charge neutralization and condensation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the kinetoplast DNA network.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, kinetoplast
CC       {ECO:0000269|PubMed:8446592, ECO:0000269|PubMed:9719509}.
CC   -!- INDUCTION: Present at a constant level throughout the cell cycle.
CC       {ECO:0000269|PubMed:9719509}.
CC   -!- SIMILARITY: Belongs to the KAP family. {ECO:0000305}.
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DR   EMBL; AF034951; AAC32801.1; -; mRNA.
DR   AlphaFoldDB; O61016; -.
DR   SMR; O61016; -.
DR   VEuPathDB; TriTrypDB:CFAC1_210045100; -.
DR   GO; GO:0020023; C:kinetoplast; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA-binding; Kinetoplast; Mitochondrion.
FT   PROPEP          1..9
FT                   /evidence="ECO:0000269|PubMed:8446592"
FT                   /id="PRO_0000409296"
FT   CHAIN           10..151
FT                   /note="Kinetoplast-associated protein 1"
FT                   /id="PRO_0000409297"
FT   REGION          13..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..151
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   151 AA;  14974 MW;  1FE6E56C02A3F0FB CRC64;
     MLRVSVRSLV RKASSKAGSK AAVPAAAAAA SAPLSPATSA ASARAVPPVG ESRVSIPPIP
     GVAAPRSHRA AAAPAKKAAA PKAAKAKTPA KASRKIKKAA SKPSAPKQAA GKMRKAAGKA
     QRKIKAAARK AAPKKMAKSF GKKGAAKKAH K