KAPA_PENRW
ID KAPA_PENRW Reviewed; 552 AA.
AC B6HJ92;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Importin subunit alpha {ECO:0000305};
DE AltName: Full=Karyopherin alpha {ECO:0000305};
GN Name=kapA; ORFNames=Pc21g01970;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
RN [2]
RP INTERACTION WITH VELA, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=20543063; DOI=10.1128/ec.00077-10;
RA Hoff B., Kamerewerd J., Sigl C., Mitterbauer R., Zadra I., Kuernsteiner H.,
RA Kueck U.;
RT "Two components of a velvet-like complex control hyphal morphogenesis,
RT conidiophore development, and penicillin biosynthesis in Penicillium
RT chrysogenum.";
RL Eukaryot. Cell 9:1236-1250(2010).
CC -!- FUNCTION: Import of proteins with classical NLS composed of one or two
CC clusters of basic residues is initiated by binding to the importin
CC alpha/beta heterodimer, where importin alpha acts as an adapter subunit
CC to bridge NLS cargos to importin beta, which transports the whole
CC complex through the nuclear envelope (By similarity). Involved in the
CC nuclear accumulation of the light-dependent developmental regulator
CC velA (PubMed:20543063). {ECO:0000250|UniProtKB:G5EB89,
CC ECO:0000269|PubMed:20543063}.
CC -!- SUBUNIT: Forms a complex with an importin beta subunit (By similarity).
CC Interacts with velA (PubMed:20543063). {ECO:0000250|UniProtKB:Q02821,
CC ECO:0000269|PubMed:20543063}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20543063}.
CC -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR EMBL; AM920436; CAP95094.1; -; Genomic_DNA.
DR RefSeq; XP_002567262.1; XM_002567216.1.
DR AlphaFoldDB; B6HJ92; -.
DR SMR; B6HJ92; -.
DR STRING; 1108849.XP_002567262.1; -.
DR EnsemblFungi; CAP95094; CAP95094; PCH_Pc21g01970.
DR GeneID; 8305406; -.
DR KEGG; pcs:Pc21g01970; -.
DR VEuPathDB; FungiDB:PCH_Pc21g01970; -.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_0_1; -.
DR OMA; EMIQMLY; -.
DR OrthoDB; 1111872at2759; -.
DR BioCyc; PCHR:PC21G01970-MON; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; -; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 1: Evidence at protein level;
KW Nucleus; Protein transport; Reference proteome; Repeat; Transport.
FT CHAIN 1..552
FT /note="Importin subunit alpha"
FT /id="PRO_0000435925"
FT DOMAIN 1..58
FT /note="IBB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT REPEAT 115..154
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 157..196
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 199..239
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 242..281
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 284..323
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 326..365
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 368..407
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 413..452
FT /note="ARM 8"
FT /evidence="ECO:0000255"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 60505 MW; 17E8B51A213D572A CRC64;
MAERYIPEHR RTQFKAKNQF KPDELRRRRE EQQVEIRKAK RDENLAKRRG IQTQDGRIGV
GGMAAATESD DEASAIESEL NVELPQMVKG VFSDQVEEQI QATTKFRKLL SKERNPPIER
VIETGVVARF VEFLRSPHTL VQFESAWALT NIASGSAQQT QVVIEAGAVP IFVELLSSPE
PDVREQAVWA LGNIAGDSPH CRDFVLGAGA LRPLLNLIND GRKLSMLRNA TWTLSNFCRG
KTPQPDWNTI APALPVLAKL IYMLDDEVLI DACWAISYLS DGANDKIQAV IEAGIPRRLV
ELLMHASTSV QTPALRSVGN IVTGDDVQTQ VIINCGSLPA LLSLLSSTKD GIRKEACWTI
SNVTAGNSSQ IQAVIDAGII APLINLLANG DFKTRKEACW AISNATSGGL QKPDQIRYLV
SQGCIKPLCD LLACPDNKII QVALDGLENI LKVGDMDKEA GQPGEARVNR YALFIEEAGG
MEKIHDCQNN ANEEIYMKAY NIIEKYFSDE DEAGGDIEEL APQQTQTGFT LGTGQQQPGG
FNFGNGGDSM DM
