ID   KAPR_COLTR              Reviewed;         404 AA.
AC   O42794;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=cAMP-dependent protein kinase regulatory subunit;
DE            Short=PKA regulatory subunit;
GN   Name=PKAR;
OS   Colletotrichum trifolii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC   Colletotrichum orbiculare species complex.
OX   NCBI_TaxID=5466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=10339807; DOI=10.1007/s002030050707;
RA   Yang Z., Dickman M.B.;
RT   "Molecular cloning and characterization of Ct-PKAR, a gene encoding the
RT   regulatory subunit of cAMP-dependent protein kinase in Colletotrichum
RT   trifolii.";
RL   Arch. Microbiol. 171:249-256(1999).
CC   -!- FUNCTION: cAMP-dependent protein kinase PKA regulatory subunit.
CC       {ECO:0000269|PubMed:10339807}.
CC   -!- SUBUNIT: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C)
CC       subunits. In the presence of cAMP it dissociates into 2 active
CC       monomeric C subunits and an R dimer (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cAMP-dependent kinase regulatory chain
CC       family. {ECO:0000305}.
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DR   EMBL; AF046922; AAC04356.1; -; Genomic_DNA.
DR   AlphaFoldDB; O42794; -.
DR   SMR; O42794; -.
DR   GO; GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.
DR   GO; GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 2.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR012198; cAMP_dep_PK_reg_su.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 2.
DR   PIRSF; PIRSF000548; PK_regulatory; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 2.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 2.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
PE   3: Inferred from homology;
KW   cAMP; cAMP-binding; Nucleotide-binding; Phosphoprotein; Repeat.
FT   CHAIN           1..404
FT                   /note="cAMP-dependent protein kinase regulatory subunit"
FT                   /id="PRO_0000205406"
FT   REGION          14..144
FT                   /note="Dimerization and phosphorylation"
FT                   /evidence="ECO:0000255"
FT   BINDING         145..276
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="1"
FT   BINDING         223
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         232
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         277..398
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="2"
FT   BINDING         344
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         353
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   404 AA;  44778 MW;  4A60317816E3FF04 CRC64;
     MAFPTYRPVQ CSKLTDHELL RIPHSPSLEP LDYCIEPISY LRRTVYDLHT TVANRSSSRA
     LLHKQPPVMF KSPFGANANP FGGASDGATV GGNAMHQYNF SRRTSVSAES LKPSADTYDN
     WTPPVHDKTN EQLSRLKTAI AGNFLFSHLD DEQSAQILGA LIEKPIPAKD IKVISQGDAG
     EYFYVVEKGS FDVYVNEKGT LQPGPEGMGE KVGTIQAGGS FGELALMYNA PRAATVISAE
     PGCTLWALDR LTFRRILMES TFLAAACTRT SSEKFPCCRH SHHMSAQKSP TRWKLRSTPL
     VRRLSRRETR VTRFTCSRWR GRCLPGEMAR ESVKHYSKGD FFGELALLND APRAASIVAT
     TDVKVASLGK SAFQRLLGPV EGIMRRTKYD DIKTGVEEMD PLQV