ID   KAPR_STRPU              Reviewed;         369 AA.
AC   Q26619;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=cAMP-dependent protein kinase type II regulatory subunit;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Rankin T.L., Dangott L.J.;
RT   "Regulatory subunit type II of cyclic AMP-dependent protein kinase
RT   localized in sea urchin spermatozoa.";
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C)
CC       subunits. In the presence of cAMP it dissociates into 2 active
CC       monomeric C subunits and an R dimer (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cAMP-dependent kinase regulatory chain
CC       family. {ECO:0000305}.
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DR   EMBL; U19887; AAA61966.1; -; mRNA.
DR   RefSeq; NP_999688.1; NM_214523.1.
DR   AlphaFoldDB; Q26619; -.
DR   SMR; Q26619; -.
DR   STRING; 7668.SPU_018419-tr; -.
DR   EnsemblMetazoa; NM_214523; NP_999688; LOC373288.
DR   GeneID; 373288; -.
DR   KEGG; spu:373288; -.
DR   eggNOG; KOG1113; Eukaryota.
DR   HOGENOM; CLU_018310_2_0_1; -.
DR   OMA; YDNWSPP; -.
DR   OrthoDB; 1047290at2759; -.
DR   PhylomeDB; Q26619; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005952; C:cAMP-dependent protein kinase complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030552; F:cAMP binding; IBA:GO_Central.
DR   GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IBA:GO_Central.
DR   GO; GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 2.
DR   Gene3D; 2.60.120.10; -; 2.
DR   InterPro; IPR012198; cAMP_dep_PK_reg_su.
DR   InterPro; IPR003117; cAMP_dep_PK_reg_su_I/II_a/b.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 2.
DR   Pfam; PF02197; RIIa; 1.
DR   PIRSF; PIRSF000548; PK_regulatory; 1.
DR   SMART; SM00100; cNMP; 2.
DR   SMART; SM00394; RIIa; 1.
DR   SUPFAM; SSF51206; SSF51206; 2.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 2.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
PE   2: Evidence at transcript level;
KW   cAMP; cAMP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Repeat.
FT   CHAIN           1..369
FT                   /note="cAMP-dependent protein kinase type II regulatory
FT                   subunit"
FT                   /id="PRO_0000205398"
FT   REGION          1..120
FT                   /note="Dimerization and phosphorylation"
FT                   /evidence="ECO:0000250"
FT   REGION          56..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         121..238
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="1"
FT   BINDING         186
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         195
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         239..365
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="2"
FT   BINDING         313
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         322
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         81
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   369 AA;  41789 MW;  30FCECC13D8C26A5 CRC64;
     MNFEIPEGLT DLLQDFTVAV LREKPSDLVE FASSYFAKLQ ENNISLGGKR GVTFTAPEDA
     ESDIDDEPPE LPKNRYARRK SVCAEKYDPE ADNDTDTQKL VYPKSDEQRA RLTEAVKNIL
     LFRALDEKQM QEVIDAMFEK KTTPGDHVID QGDDGDNFYV IDRGEYDIFV NDNKVGAYKD
     SGSFGELALM YNTPRAATIA ATTDGILWAL DRVSFRRIVL KNAAKKRRIY EELLEKVSIF
     KSLEPYERMN LADALVTRTY EDGDCIIAQG DGADGCYFIE AGQCRIAMKS ERSDNPDEEK
     EVAIYNQGQY FGELALLTNK PRAASVYAVE DVDCLLDVNA FERLLGPCMD IMKRNIEHYE
     QETSRLFGK