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KAR5_CANAL
ID   KAR5_CANAL              Reviewed;         485 AA.
AC   Q59WU8; A0A1D8PPH8; A0A1D8PPH9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Nuclear fusion protein KAR5;
DE   AltName: Full=Karyogamy protein 5;
DE   Flags: Precursor;
GN   Name=KAR5; OrderedLocusNames=CAALFM_C601010WA, CAALFM_C601020WA;
GN   ORFNames=CaO19.7750, orf19.103, orf19.104;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AOW30047.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AOW30047.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AOW30047.1; Type=Miscellaneous discrepancy; Note=Contains ambiguous sequence between ORF C6_01010W_A and C6_01020W_A. Used assembly 19 sequence to merge the 2 ORFs.; Evidence={ECO:0000305|PubMed:15123810, ECO:0000305|PubMed:24025428};
CC       Sequence=AOW30048.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AOW30048.1; Type=Miscellaneous discrepancy; Note=Contains ambiguous sequence between ORF C6_01010W_A and C6_01020W_A. Used assembly 19 sequence to merge the 2 ORFs.; Evidence={ECO:0000305|PubMed:15123810, ECO:0000305|PubMed:24025428};
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DR   EMBL; CP017628; AOW30047.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP017628; AOW30048.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_714312.2; XM_709219.2.
DR   RefSeq; XP_714313.1; XM_709220.2.
DR   AlphaFoldDB; Q59WU8; -.
DR   SMR; Q59WU8; -.
DR   STRING; 237561.Q59WU8; -.
DR   GeneID; 3644049; -.
DR   GeneID; 3644050; -.
DR   KEGG; cal:CAALFM_C601010WA; -.
DR   KEGG; cal:CAALFM_C601020WA; -.
DR   CGD; CAL0000183563; KAR5.
DR   CGD; CAL0000191239; orf19.104.
DR   HOGENOM; CLU_039530_0_0_1; -.
DR   InParanoid; Q59WU8; -.
DR   OrthoDB; 1476880at2759; -.
DR   Proteomes; UP000000559; Chromosome 6.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0031301; C:integral component of organelle membrane; IBA:GO_Central.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IBA:GO_Central.
DR   GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:InterPro.
DR   InterPro; IPR007292; Nuclear_fusion_Kar5.
DR   PANTHER; PTHR28012; PTHR28012; 1.
DR   Pfam; PF04163; Tht1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Karyogamy; Membrane; Nucleus;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..485
FT                   /note="Nuclear fusion protein KAR5"
FT                   /id="PRO_0000308770"
FT   TOPO_DOM        16..423
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        445..450
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        472..485
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        344
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        370
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   485 AA;  56008 MW;  8C06EE251E03D0C3 CRC64;
     MNIVLLIYCL AMVVAHDLQL FGDFKFELSD NWRNDCAKKA LEPIINQCAE GIETISPFQQ
     KSIAIQLSIC EFENAEISYP SECRSQNLDT CILLLEKSPQ YWTTFSGYYR EIRNICHQVS
     LPFAKDQILQ VYGNITEFYR TLMDEMTNSS KYTENMQNEL KAKFDKLIGV IDLILADREK
     NREDLKSSFN MFKNNFEKSL NNALVVMKHS YEDANSNVKE LESHLNYFIN DMSQVYILIN
     EKALEVKSQQ DRIKEHNADI LNQIEEIKKN LDNAYEEASE VQISNNQLVH DIQSSLDYSL
     FTVSNLNSHL QLSINDFIEK NEDIRSRAPI IFEEIFGLFL NHLNESGQLA MDSFEAALDL
     SLNMLHQKLN QTERSIDNLN SKVSDLAHFA DSLKKYASSI FNVPNYVRTS MNHKIQQWRE
     FGNIMVVGGV FFFVVLTLLV LSFIRTQVMK VFRFAFIGIP MITGIALAIF ILRLLSMPMK
     VVDID
 
 
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