ID   KAS1_STRCM              Reviewed;         420 AA.
AC   P41175;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 1;
DE            EC=2.3.1.-;
DE   AltName: Full=ORF1;
OS   Streptomyces cinnamonensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces virginiae group.
OX   NCBI_TaxID=1900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3823.5;
RX   PubMed=1508151; DOI=10.1007/bf00283846;
RA   Arrowsmith T.J., Malpartida F., Sherman D.H., Birch A., Hopwood D.A.,
RA   Robinson J.A.;
RT   "Characterisation of actI-homologous DNA encoding polyketide synthase genes
RT   from the monensin producer Streptomyces cinnamonensis.";
RL   Mol. Gen. Genet. 234:254-264(1992).
CC   -!- PATHWAY: Antifungal biosynthesis; monensin biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; Z11511; CAA77596.1; -; Genomic_DNA.
DR   PIR; S25076; S25076.
DR   AlphaFoldDB; P41175; -.
DR   SMR; P41175; -.
DR   UniPathway; UPA00178; -.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00834; KAS_I_II; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Transferase.
FT   CHAIN           1..420
FT                   /note="Putative polyketide beta-ketoacyl synthase 1"
FT                   /id="PRO_0000180335"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ   SEQUENCE   420 AA;  44453 MW;  B2CB06277DE39391 CRC64;
     MTQRRVAITG IEVLAPGGLG RKEFWQLLSE GRTATRGITF FDPAPFRSKV AAEADFCGLE
     NGLSPQEVRR MDRAAQFAVV TARAVEDSGA ELAAHPPHRI GVVVGSAVGA TMGLDNEYRV
     VSDGGRLDLV DHRYAVPHLY NYLVPSSFAA EVAWAVGAEG PSTVVSTGCT SGIDAVGIAV
     ELVREGSVDV MVAGAVDAPI SPIPCVLDAI KATTPRHDAP ATASRPFDST RNGFVLGEGA
     AFFVLEELHS ARRRGAHIYA EIAGYATRSN AYHMTGLRDG AEMAEAIRLA LDEARLNPEQ
     VDYINAHGSG TKQNDRHETA AFKKALGEHA YRTPVSSIKS MVGHSLGAIG SIEIAASALA
     MEYDVVPPTA NLHTPDPECD LDYVPLTARD QRVDSVLTVG SGFGGFQSAM VLTSAQRSTV