ID   KAS1_STRCN              Reviewed;         422 AA.
AC   Q02578;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 1;
DE            EC=2.3.1.-;
GN   Name=curA;
OS   Streptomyces cyaneus (Streptomyces curacoi).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1904;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13385 / CBS 484.68 / DSM 40107 / JCM 4219 / NBRC 12761 / NRRL
RC   B-2901 / VKM Ac-621;
RX   PubMed=1644304; DOI=10.1016/0378-1119(92)90501-f;
RA   Bergh S., Uhlen M.;
RT   "Analysis of a polyketide synthesis-encoding gene cluster of Streptomyces
RT   curacoi.";
RL   Gene 117:131-136(1992).
CC   -!- PATHWAY: Antibiotic biosynthesis; curamycin biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X62518; CAA44380.1; -; Genomic_DNA.
DR   EMBL; M33704; AAA26726.1; -; Genomic_DNA.
DR   PIR; JC1210; JC1210.
DR   AlphaFoldDB; Q02578; -.
DR   SMR; Q02578; -.
DR   UniPathway; UPA00176; -.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00834; KAS_I_II; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Transferase.
FT   CHAIN           1..422
FT                   /note="Putative polyketide beta-ketoacyl synthase 1"
FT                   /id="PRO_0000180336"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ   SEQUENCE   422 AA;  44727 MW;  E077D87C0B833441 CRC64;
     MTRRVAVTGI GVVAPGGIGV PAFWDLLSSG RTATRGITLF DPEGLRSRIA AECDFDPLAH
     GLDPELVERA DRYIQFALVA ADEAVTDSGI DFGTENPWRV AVSLGSAVGG TTRLEHDYVL
     VSERGQRWDV DHRAAEPELH RAFSPSTLAA DVAERFGAQG PVQTVSTGCT SGLDAVGYAF
     HTIEEGRADV CIAGASDSPI SPITMACFDA IKATSPNNDD PEHASRPFDA HRDGFVMGEG
     AAVLVLEELE HARARGAHVY CEIGGYATFG NAYHMTGLTS EGLEMARAID VALDHARVDP
     TDIDYVNAHG SGTRQNDRHE TAAVKKSLGA HAYDTPMSSI KSMVGHSLGA IGAIEVVACV
     LALARQVVPP TANYETPDPE CDLDYVPRTA RPRRLDHVLS VGSGFGGFQS AVLLTGPAGR
     KR