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KAS1_STRCO
ID   KAS1_STRCO              Reviewed;         423 AA.
AC   P23155;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 1;
DE            EC=2.3.1.-;
DE   AltName: Full=WhiE ORF III;
GN   OrderedLocusNames=SCO5318; ORFNames=SC6G9.15;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=2077356; DOI=10.1111/j.1365-2958.1990.tb00545.x;
RA   Davis N.K., Chater K.F., Bruton C.J.;
RT   "Spore colour in Streptomyces coelicolor A3(2) involves the developmentally
RT   regulated synthesis of a compound biosynthetically related to polyketide
RT   antibiotics.";
RL   Mol. Microbiol. 4:1679-1691(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Involved in developmentally regulated synthesis of a compound
CC       biosynthetically related to polyketide antibiotics which is essential
CC       for spore color in Streptomyces coelicolor.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X55942; CAA39408.1; -; Genomic_DNA.
DR   EMBL; AL939123; CAB45606.1; -; Genomic_DNA.
DR   PIR; S11974; S11974.
DR   RefSeq; NP_629460.1; NC_003888.3.
DR   RefSeq; WP_003973654.1; NZ_VNID01000040.1.
DR   AlphaFoldDB; P23155; -.
DR   SMR; P23155; -.
DR   STRING; 100226.SCO5318; -.
DR   GeneID; 1100758; -.
DR   KEGG; sco:SCO5318; -.
DR   PATRIC; fig|100226.15.peg.5404; -.
DR   eggNOG; COG0304; Bacteria.
DR   HOGENOM; CLU_000022_69_2_11; -.
DR   InParanoid; P23155; -.
DR   OMA; YRYIKYK; -.
DR   PhylomeDB; P23155; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IBA:GO_Central.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR   CDD; cd00834; KAS_I_II; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..423
FT                   /note="Putative polyketide beta-ketoacyl synthase 1"
FT                   /id="PRO_0000180341"
FT   ACT_SITE        170
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ   SEQUENCE   423 AA;  44815 MW;  195E895027404A43 CRC64;
     MTRRRVAVTG IGVVAPGGIG TPQFWRLLSE GRTATRRISL FDPSGLRSQI AAECDFEPSD
     HGLGLATAQR CDRYVQFALV AASEAVRDAN LDMNREDPWR AGATLGTAVG GTTRLEHDYV
     LVSERGSRWD VDDRRSEPHL ERAFTPATLS SAVAEEFGVR GPVQTVSTGC TSGLDAVGYA
     YHAVAEGRVD VCLAGAADSP ISPITMACFD AIKATSPNND DPAHASRPFD ADRNGFVMGE
     GAAVLVLEDL EHARARGADV YCEVSGYATF GNAYHMTGLT KEGLEMARAI DTALDMAELD
     GSAIDYVNAH GSGTQQNDRH ETAAVKRSLG EHAYATPMSS IKSMVGHSLG AIGSIELAAC
     VLAMAHQVVP PTANYTTPDP ECDLDYVPRE ARERTLRHVL SVGSGFGGFQ SAVVLSGSEG
     GLR
 
 
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