ID   KAS1_STRGA              Reviewed;         426 AA.
AC   P16538;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Tetracenomycin C polyketide putative beta-ketoacyl synthase 1;
DE            EC=2.3.1.-;
GN   Name=tcmK;
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RX   PubMed=2684656; DOI=10.1002/j.1460-2075.1989.tb08414.x;
RA   Bibb M.J., Biro S., Motamedi H., Collins J.F., Hutchinson C.R.;
RT   "Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI
RT   genes provides key information about the enzymology of polyketide
RT   antibiotic biosynthesis.";
RL   EMBO J. 8:2727-2736(1989).
CC   -!- PATHWAY: Antibiotic biosynthesis; tetracenomycin C biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X15312; CAA33369.1; -; Genomic_DNA.
DR   EMBL; M80674; AAA67515.1; -; Genomic_DNA.
DR   PIR; S05973; S05973.
DR   RefSeq; WP_043504915.1; NZ_CP009438.1.
DR   AlphaFoldDB; P16538; -.
DR   SMR; P16538; -.
DR   STRING; 1907.SGLAU_26355; -.
DR   eggNOG; COG0304; Bacteria.
DR   OMA; MNNNFAF; -.
DR   OrthoDB; 606297at2; -.
DR   BioCyc; MetaCyc:MON-18610; -.
DR   BRENDA; 2.3.1.235; 6020.
DR   UniPathway; UPA00174; -.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00834; KAS_I_II; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Transferase.
FT   CHAIN           1..426
FT                   /note="Tetracenomycin C polyketide putative beta-ketoacyl
FT                   synthase 1"
FT                   /id="PRO_0000180337"
FT   ACT_SITE        173
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ   SEQUENCE   426 AA;  45077 MW;  8B0E0BD03C510643 CRC64;
     MTRHAEKRVV ITGIGVRAPG GAGTAAFWDL LTAGRTATRT ISLFDAAPYR SRIAGEIDFD
     PIGEGLSPRQ ASTYDRATQL AVVCAREALK DSGLDPAAVN PERIGVSIGT AVGCTTGLDR
     EYARVSEGGS RWLVDHTLAV EQLFDYFVPT SICREVAWEA GAEGPVTVVS TGCTSGLDAV
     GYGTELIRDG RADVVVCGAT DAPISPITVA CFDAIKATSA NNDDPAHASR PFDRNRDGFV
     LGEGSAVFVL EELSAARRRG AHAYAEVRGF ATRSNAFHMT GLKPDGREMA EAITAALDQA
     RRTGDDLHYI NAHGSGTRQN DRHETAAFKR SLGQRAYDVP VSSIKSMIGH SLGAIGSLEL
     AACALAIEHG VIPPTANYEE PDPECDLDYV PNVAREQRVD TVLSVGSGFG GFQSAAVLAR
     PKETRS