KAS1_STRGA
ID KAS1_STRGA Reviewed; 426 AA.
AC P16538;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Tetracenomycin C polyketide putative beta-ketoacyl synthase 1;
DE EC=2.3.1.-;
GN Name=tcmK;
OS Streptomyces glaucescens.
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces.
OX NCBI_TaxID=1907;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RX PubMed=2684656; DOI=10.1002/j.1460-2075.1989.tb08414.x;
RA Bibb M.J., Biro S., Motamedi H., Collins J.F., Hutchinson C.R.;
RT "Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI
RT genes provides key information about the enzymology of polyketide
RT antibiotic biosynthesis.";
RL EMBO J. 8:2727-2736(1989).
CC -!- PATHWAY: Antibiotic biosynthesis; tetracenomycin C biosynthesis.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000305}.
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DR EMBL; X15312; CAA33369.1; -; Genomic_DNA.
DR EMBL; M80674; AAA67515.1; -; Genomic_DNA.
DR PIR; S05973; S05973.
DR RefSeq; WP_043504915.1; NZ_CP009438.1.
DR AlphaFoldDB; P16538; -.
DR SMR; P16538; -.
DR STRING; 1907.SGLAU_26355; -.
DR eggNOG; COG0304; Bacteria.
DR OMA; MNNNFAF; -.
DR OrthoDB; 606297at2; -.
DR BioCyc; MetaCyc:MON-18610; -.
DR BRENDA; 2.3.1.235; 6020.
DR UniPathway; UPA00174; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712; PTHR11712; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; SSF53901; 1.
DR PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Antibiotic biosynthesis; Transferase.
FT CHAIN 1..426
FT /note="Tetracenomycin C polyketide putative beta-ketoacyl
FT synthase 1"
FT /id="PRO_0000180337"
FT ACT_SITE 173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ SEQUENCE 426 AA; 45077 MW; 8B0E0BD03C510643 CRC64;
MTRHAEKRVV ITGIGVRAPG GAGTAAFWDL LTAGRTATRT ISLFDAAPYR SRIAGEIDFD
PIGEGLSPRQ ASTYDRATQL AVVCAREALK DSGLDPAAVN PERIGVSIGT AVGCTTGLDR
EYARVSEGGS RWLVDHTLAV EQLFDYFVPT SICREVAWEA GAEGPVTVVS TGCTSGLDAV
GYGTELIRDG RADVVVCGAT DAPISPITVA CFDAIKATSA NNDDPAHASR PFDRNRDGFV
LGEGSAVFVL EELSAARRRG AHAYAEVRGF ATRSNAFHMT GLKPDGREMA EAITAALDQA
RRTGDDLHYI NAHGSGTRQN DRHETAAFKR SLGQRAYDVP VSSIKSMIGH SLGAIGSLEL
AACALAIEHG VIPPTANYEE PDPECDLDYV PNVAREQRVD TVLSVGSGFG GFQSAAVLAR
PKETRS