KAS1_STRHA
ID KAS1_STRHA Reviewed; 422 AA.
AC Q05356;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Putative polyketide beta-ketoacyl synthase 1;
DE Short=KS;
DE EC=2.3.1.-;
DE AltName: Full=Polyketide condensing enzyme;
GN Name=sch1;
OS Streptomyces halstedii.
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces.
OX NCBI_TaxID=1944;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NRRL 2381;
RX PubMed=8344517; DOI=10.1016/0378-1119(93)90352-4;
RA Blanco G., Brian P., Pereda A., Mendez C., Salas J.A., Chater K.F.;
RT "Hybridization and DNA sequence analyses suggest an early evolutionary
RT divergence of related biosynthetic gene sets encoding polyketide
RT antibiotics and spore pigments in Streptomyces spp.";
RL Gene 130:107-116(1993).
CC -!- FUNCTION: Involved in developmentally regulated synthesis of a compound
CC biosynthetically related to polyketide antibiotics which is essential
CC for spore color in Streptomyces halstedii.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L05390; AAA02833.1; -; Genomic_DNA.
DR PIR; JN0825; JN0825.
DR AlphaFoldDB; Q05356; -.
DR SMR; Q05356; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712; PTHR11712; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; SSF53901; 2.
DR PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Transferase.
FT CHAIN 1..422
FT /note="Putative polyketide beta-ketoacyl synthase 1"
FT /id="PRO_0000180338"
FT ACT_SITE 169
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ SEQUENCE 422 AA; 44986 MW; 64B86F0B6007FCC2 CRC64;
MSRRVVVTGI GVVAPGGIGA ARFWDLLAGG RTATRRISLF DPARLRSQIA AECDFDPSAH
GLDDETVRRC DRYVQFALVA TAEAVRDAGL DTTREDPWRM GAVLGTAVGG TTRLEHDYVL
VSEGGSRWDV DHRRAEPHLH RAFAPSTLAS TVAETFGAQG PVQTVSTGCT SGLDAVGYAY
HAIAEGRADV CLAGASDSPI SPITMACFDA IKATSPSNDD PEHASRPFDA RRNGFVMGEG
GAVLVLEELE HARARGADVY CELAGYATFG NAHHMTGLTR EGLEMARAID TALDMARLDG
TDIDYVNAHG SGTQQNDRHE TAAVKRSLGE HAYRTPMSSI KSMVGHSLGA IGSIEVVACV
LALAHQVVPP TANYETPDPE CDLDYVPREA RERELRSVLS VGSGFGGFQS AVVLTGPERR
LR