ID   KAS1_STRHA              Reviewed;         422 AA.
AC   Q05356;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 1;
DE            Short=KS;
DE            EC=2.3.1.-;
DE   AltName: Full=Polyketide condensing enzyme;
GN   Name=sch1;
OS   Streptomyces halstedii.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL 2381;
RX   PubMed=8344517; DOI=10.1016/0378-1119(93)90352-4;
RA   Blanco G., Brian P., Pereda A., Mendez C., Salas J.A., Chater K.F.;
RT   "Hybridization and DNA sequence analyses suggest an early evolutionary
RT   divergence of related biosynthetic gene sets encoding polyketide
RT   antibiotics and spore pigments in Streptomyces spp.";
RL   Gene 130:107-116(1993).
CC   -!- FUNCTION: Involved in developmentally regulated synthesis of a compound
CC       biosynthetically related to polyketide antibiotics which is essential
CC       for spore color in Streptomyces halstedii.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; L05390; AAA02833.1; -; Genomic_DNA.
DR   PIR; JN0825; JN0825.
DR   AlphaFoldDB; Q05356; -.
DR   SMR; Q05356; -.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00834; KAS_I_II; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..422
FT                   /note="Putative polyketide beta-ketoacyl synthase 1"
FT                   /id="PRO_0000180338"
FT   ACT_SITE        169
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ   SEQUENCE   422 AA;  44986 MW;  64B86F0B6007FCC2 CRC64;
     MSRRVVVTGI GVVAPGGIGA ARFWDLLAGG RTATRRISLF DPARLRSQIA AECDFDPSAH
     GLDDETVRRC DRYVQFALVA TAEAVRDAGL DTTREDPWRM GAVLGTAVGG TTRLEHDYVL
     VSEGGSRWDV DHRRAEPHLH RAFAPSTLAS TVAETFGAQG PVQTVSTGCT SGLDAVGYAY
     HAIAEGRADV CLAGASDSPI SPITMACFDA IKATSPSNDD PEHASRPFDA RRNGFVMGEG
     GAVLVLEELE HARARGADVY CELAGYATFG NAHHMTGLTR EGLEMARAID TALDMARLDG
     TDIDYVNAHG SGTQQNDRHE TAAVKRSLGE HAYRTPMSSI KSMVGHSLGA IGSIEVVACV
     LALAHQVVPP TANYETPDPE CDLDYVPREA RERELRSVLS VGSGFGGFQS AVVLTGPERR
     LR