ID   KAS1_STRRM              Reviewed;         425 AA.
AC   P43678;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Oxytetracycline polyketide putative beta-ketoacyl synthase 1;
OS   Streptomyces rimosus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1927;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8163168; DOI=10.1016/0378-1119(94)90144-9;
RA   Kim E.S., Bibb M.J., Butler M.J., Hopwood D.A., Sherman D.H.;
RT   "Sequences of the oxytetracycline polyketide synthase-encoding otc genes
RT   from Streptomyces rimosus.";
RL   Gene 141:141-142(1994).
CC   -!- PATHWAY: Antibiotic biosynthesis; oxytetracycline biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; Z25538; CAA80985.1; -; Genomic_DNA.
DR   AlphaFoldDB; P43678; -.
DR   SMR; P43678; -.
DR   UniPathway; UPA00926; -.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd00834; KAS_I_II; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Transferase.
FT   CHAIN           1..425
FT                   /note="Oxytetracycline polyketide putative beta-ketoacyl
FT                   synthase 1"
FT                   /id="PRO_0000180339"
FT   ACT_SITE        173
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10022"
SQ   SEQUENCE   425 AA;  45005 MW;  B350D6D589887438 CRC64;
     MSKIHDARRV VITGIGVVAP GDVGTKPFWE MLTAGRTATR PISSFDASPF RSQVAAECDF
     DPAAEGLSQR QVRAWDRTMQ FAYVAAREAL ADSGVTGEAD PLRTGVMAGT ACGMTMSLDR
     EYAVVSDEGR LWQVDDAHGV PYLYDYFVPS SMAAEIAWLA EAEGPAGVVS AGCTSGIDVL
     THAADLVRDG AAEVMVAGAS DAAISPITVA CFDAIKATTP RNDEPETASR PFDRTRNGFV
     LGEGAAFFVL EEYAHARRRG ARAYAEIAGY AGRCNAYSMT GLRSDGRELA EAVSRALDIA
     RVDPSEVDYV NAHGSATKQN DLHETAAFKR SLGPHAYSVP ISSIKSMIGH SLGAICALEV
     AASALRIEHG VIPPTANLRE PDPDCDLDYV PLVAREAEVS TVVSVASGFG GFQSAIVLTE
     PGRQR