ID   KAS2_STRCM              Reviewed;         402 AA.
AC   P41176;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 2;
DE            EC=2.3.1.-;
DE   AltName: Full=ORF 2;
OS   Streptomyces cinnamonensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces virginiae group.
OX   NCBI_TaxID=1900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3823.5;
RX   PubMed=1508151; DOI=10.1007/bf00283846;
RA   Arrowsmith T.J., Malpartida F., Sherman D.H., Birch A., Hopwood D.A.,
RA   Robinson J.A.;
RT   "Characterisation of actI-homologous DNA encoding polyketide synthase genes
RT   from the monensin producer Streptomyces cinnamonensis.";
RL   Mol. Gen. Genet. 234:254-264(1992).
CC   -!- PATHWAY: Antifungal biosynthesis; monensin biosynthesis.
CC   -!- MISCELLANEOUS: This putative ketoacyl synthase lacks the active site
CC       cysteine.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; Z11511; CAA77597.1; -; Genomic_DNA.
DR   PIR; S25077; S25077.
DR   AlphaFoldDB; P41176; -.
DR   SMR; P41176; -.
DR   UniPathway; UPA00178; -.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Transferase.
FT   CHAIN           1..402
FT                   /note="Putative polyketide beta-ketoacyl synthase 2"
FT                   /id="PRO_0000180343"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  41271 MW;  348657D10201C214 CRC64;
     MTPVAVTGMG IAAPNGLGRP TTGRPPWAPR AASAASTRFD PSGYPAQLAG EIPGFRAAEH
     LPGRLVPQTD RVTRLSLAAA DWALADAGVE VAAFDPLDMG VVTASHAGGF EFGQDELQKL
     LGQGQPVLSA YQSFAWFYAV NSGQISIRHG MKGPSGVVVS DQAGGLDALA QARRLVRKGT
     PLIVCGAVEP RSAPGAGSPS SPAGGMSDSD EPNRAYLPFD RDGRGYVPGG GRGVVPPLER
     AEAAPARGAE VYGEAGPLAR LPAPHSGRGS TRAHAIRTAL DDAGTAPGDI RRVFADGGGR
     YPNDRAEAEA ISEVFGPGRV PVTCPRTMTG RLHSGAAPLD VACALLAMRA GVIPPTVHID
     PCPEYDLDLV LYQVRPAALR TALGGARGHG GFNSALVVRA GQ