ID   KAS2_STRCN              Reviewed;         419 AA.
AC   Q02579;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 2;
DE            EC=2.3.1.-;
GN   Name=curB;
OS   Streptomyces cyaneus (Streptomyces curacoi).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1904;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 13385 / CBS 484.68 / DSM 40107 / JCM 4219 / NBRC 12761 / NRRL
RC   B-2901 / VKM Ac-621;
RX   PubMed=1644304; DOI=10.1016/0378-1119(92)90501-f;
RA   Bergh S., Uhlen M.;
RT   "Analysis of a polyketide synthesis-encoding gene cluster of Streptomyces
RT   curacoi.";
RL   Gene 117:131-136(1992).
CC   -!- PATHWAY: Antibiotic biosynthesis; curamycin biosynthesis.
CC   -!- MISCELLANEOUS: This putative ketoacyl synthase lacks the active site
CC       cysteine.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X62518; CAA44381.1; -; Genomic_DNA.
DR   EMBL; M33704; AAA26727.1; -; Genomic_DNA.
DR   PIR; JC1211; JC1211.
DR   AlphaFoldDB; Q02579; -.
DR   SMR; Q02579; -.
DR   PRIDE; Q02579; -.
DR   UniPathway; UPA00176; -.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Transferase.
FT   CHAIN           1..419
FT                   /note="Putative polyketide beta-ketoacyl synthase 2"
FT                   /id="PRO_0000180344"
SQ   SEQUENCE   419 AA;  42974 MW;  45305F1EF2364CA2 CRC64;
     MNGSGSGIRT RRTAVTGIGV VAPNGLHADT YWKSVKEGAS VLDRITREGC EHLPLRVAGE
     VRGFDPSALI EETFLVQTDL FTHFALAAAD AALQDAGLTK AAAVADSPYS VGVVTAAGSG
     GGEFGQRELQ KLWGQGSRFV GPYQSIAWFY AASTGQISIR SGFKGPCGVV ASDEAGGLDA
     VAHAARVVER GTDVVVVGAA EAPLAPYSMV CQLGYPELST DEDPAIAYRP FTSAARGFVP
     AEGGAVLIVE EADRAHRRGA VVRATVAGHA ATFTGASHWD QSREGLAHAI HGALDEAGCA
     PEEIDVVFAD AMGVPEADRA EALALVDALG RHAPRVPVTA PKTGIGRSYC GAALLDIAAG
     AGMEHGQIPP TPNVFDICHQ IDLVTATARP ASSAPLVLSR GLMGSNAALV LRPGPGSTA