ID   KAS2_STRCO              Reviewed;         424 AA.
AC   P23156;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 2;
DE            EC=2.3.1.-;
DE   AltName: Full=WhiE ORF IV;
GN   OrderedLocusNames=SCO5317; ORFNames=SC6G9.16;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=2077356; DOI=10.1111/j.1365-2958.1990.tb00545.x;
RA   Davis N.K., Chater K.F., Bruton C.J.;
RT   "Spore colour in Streptomyces coelicolor A3(2) involves the developmentally
RT   regulated synthesis of a compound biosynthetically related to polyketide
RT   antibiotics.";
RL   Mol. Microbiol. 4:1679-1691(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Involved in developmentally regulated synthesis of a compound
CC       biosynthetically related to polyketide antibiotics which is essential
CC       for spore color in Streptomyces coelicolor.
CC   -!- MISCELLANEOUS: This putative ketoacyl synthase lacks the active site
CC       cysteine.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X55942; CAA39409.1; -; Genomic_DNA.
DR   EMBL; AL939123; CAB45607.1; -; Genomic_DNA.
DR   PIR; S11975; S11975.
DR   RefSeq; NP_629459.1; NC_003888.3.
DR   RefSeq; WP_011030171.1; NZ_VNID01000040.1.
DR   AlphaFoldDB; P23156; -.
DR   SMR; P23156; -.
DR   STRING; 100226.SCO5317; -.
DR   GeneID; 1100757; -.
DR   KEGG; sco:SCO5317; -.
DR   PATRIC; fig|100226.15.peg.5403; -.
DR   eggNOG; COG0304; Bacteria.
DR   HOGENOM; CLU_000022_69_2_11; -.
DR   InParanoid; P23156; -.
DR   OMA; RAYCGAP; -.
DR   PhylomeDB; P23156; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IBA:GO_Central.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..424
FT                   /note="Putative polyketide beta-ketoacyl synthase 2"
FT                   /id="PRO_0000180348"
SQ   SEQUENCE   424 AA;  43558 MW;  81431A6CBD200EE5 CRC64;
     MSGPQRTGTG GGSRRAVVTG LGVLSPHGTG VEAHWKAVAD GTSSLGPVTR EGCAHLPLRV
     AGEVHGFDAA ETVEDRFLVQ TDRFTHFALS ATQHALADAR FGRADVDSPY SVGVVTAAGS
     GGGEFGQREL QNLWGHGSRH VGPYQSIAWF YAASTGQVSI RNDFKGPCGV VAADEAGGLD
     ALAHAALAVR NGTDTVVCGA TEAPLAPYSI VCQLGYPELS RATEPDRAYR PFTEAACGFA
     PAEGGAVLVV EEEAAARERG ADVRATVAGH AATFTGAGRW AESREGLARA IQGALAEAGC
     RPEEVDVVFA DALGVPEADR AEALALADAL GPHAARVPVT APKTGTGRAY CAAPVLDVAT
     AVLAMEHGLI PPTPHVLDVC HDLDLVTGRA RPAEPRTALV LARGLMGSNS ALVLRRGAVP
     PEGR