ID   KAS2_STRGA              Reviewed;         409 AA.
AC   P16539;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Tetracenomycin C polyketide putative beta-ketoacyl synthase 2;
DE            EC=2.3.1.-;
GN   Name=tcmL;
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RX   PubMed=2684656; DOI=10.1002/j.1460-2075.1989.tb08414.x;
RA   Bibb M.J., Biro S., Motamedi H., Collins J.F., Hutchinson C.R.;
RT   "Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI
RT   genes provides key information about the enzymology of polyketide
RT   antibiotic biosynthesis.";
RL   EMBO J. 8:2727-2736(1989).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=1592819; DOI=10.1128/jb.174.11.3651-3658.1992;
RA   Guilfoile P.G., Hutchinson C.R.;
RT   "Sequence and transcriptional analysis of the Streptomyces glaucescens
RT   tcmAR tetracenomycin C resistance and repressor gene loci.";
RL   J. Bacteriol. 174:3651-3658(1992).
CC   -!- PATHWAY: Antibiotic biosynthesis; tetracenomycin C biosynthesis.
CC   -!- MISCELLANEOUS: This putative ketoacyl synthase lacks the active site
CC       cysteine.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X15312; CAB38455.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; M80674; AAA67516.1; -; Genomic_DNA.
DR   PIR; S05974; S05974.
DR   PIR; S27694; S27694.
DR   RefSeq; WP_043504917.1; NZ_CP009438.1.
DR   AlphaFoldDB; P16539; -.
DR   SMR; P16539; -.
DR   STRING; 1907.SGLAU_26360; -.
DR   eggNOG; COG0304; Bacteria.
DR   OMA; TDHMTRL; -.
DR   OrthoDB; 606297at2; -.
DR   BioCyc; MetaCyc:MON-18611; -.
DR   UniPathway; UPA00174; -.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic biosynthesis; Transferase.
FT   CHAIN           1..409
FT                   /note="Tetracenomycin C polyketide putative beta-ketoacyl
FT                   synthase 2"
FT                   /id="PRO_0000180345"
SQ   SEQUENCE   409 AA;  42298 MW;  E5888D2DAF3DAE62 CRC64;
     MSAPAPVVVT GLGIVAPNGT GTEEYWAATL AGKSGIDVIQ RFDPHGYPVR VGGEVLAFDA
     AAHLPGRLLP QTDRMTQHAL VAAEWALADA GLEPEKQDEY GLGVLTAAGA GGFEFGQREM
     QKLWGTGPER VSAYQSFAWF YAVNTGQISI RHGMRGHSSV FVTEQAGGLD AAAHAARLLR
     KGTLNTALTG GCEASLCPWG LVAQIPSGFL SEATDPHDAY LPFDARAAGY VPGEGGAMLV
     AERADSARER DAATVYGRIA GHASTFDARP GTGRPTGPAR AIRLALEEAR VAPEDVDVVY
     ADAAGVPALD RAEAEALAEV FGPGAVPVTA PKTMTGRLYA GGAALDVATA LLSIRDCVVP
     PTVGTGAPAP GLGIDLVLHQ PRELRVDTAL VVARGMGGFN SALVVRRHG