ID   KAS2_STRHA              Reviewed;         414 AA.
AC   Q05357;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Putative polyketide beta-ketoacyl synthase 2;
DE            Short=KS;
DE            EC=2.3.1.-;
DE   AltName: Full=Polyketide condensing enzyme;
GN   Name=sch2;
OS   Streptomyces halstedii.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL 2381;
RX   PubMed=8344517; DOI=10.1016/0378-1119(93)90352-4;
RA   Blanco G., Brian P., Pereda A., Mendez C., Salas J.A., Chater K.F.;
RT   "Hybridization and DNA sequence analyses suggest an early evolutionary
RT   divergence of related biosynthetic gene sets encoding polyketide
RT   antibiotics and spore pigments in Streptomyces spp.";
RL   Gene 130:107-116(1993).
CC   -!- FUNCTION: Involved in developmentally regulated synthesis of a compound
CC       biosynthetically related to polyketide antibiotics which is essential
CC       for spore color in Streptomyces halstedii.
CC   -!- MISCELLANEOUS: This putative ketoacyl synthase lacks the active site
CC       cysteine.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000305}.
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DR   EMBL; L05390; AAA02834.1; -; Genomic_DNA.
DR   PIR; JN0826; JN0826.
DR   AlphaFoldDB; Q05357; -.
DR   SMR; Q05357; -.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR000794; Beta-ketoacyl_synthase.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11712; PTHR11712; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..414
FT                   /note="Putative polyketide beta-ketoacyl synthase 2"
FT                   /id="PRO_0000180346"
SQ   SEQUENCE   414 AA;  42777 MW;  8736DED6E39E432E CRC64;
     MSAPRRAVVT GLGVVAPHGI GAETFWKTAV DGTSSLARID REGCGHLPLK IAGQVPDFDP
     AALIEDTYLV QTDRFTHFAM AATQLALDDA RLSRADIDSP YSVGVVTAAG SGGGEFGQRE
     LQKLWGQGSK YVGPYQSIAW FYAASTGQIS IRGGFKGPCG VVAADEAGGL DALAHAALAV
     RRGTATVVAG ATEAPLAPYS MVCQLGYPEL SRSADPGRAY RPFTSAACGF VPAEGGAMFV
     LEEEGAARER GADARATVAG HAATFTGASR WEESRAGLAH AIGTALARAG CRPQDVDVVF
     ADALGVPEAD RAEALALADA LGPHARRVPV TAPKAGIGRA FCAAAVLDVA TALLAMEHEL
     IPPTPHVLDV CHDLDLVVGR ARPARPRTAL VLSRGLMGNN SALVLRRGAA PFPE