ID   KATIP_CAEEL             Reviewed;         568 AA.
AC   O44770;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   07-APR-2021, sequence version 3.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Protein KATNIP homolog;
GN   ORFNames=K04F10.2 {ECO:0000312|WormBase:K04F10.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=26714646; DOI=10.1186/s13059-015-0858-z;
RA   Sanders A.A., de Vrieze E., Alazami A.M., Alzahrani F., Malarkey E.B.,
RA   Sorusch N., Tebbe L., Kuhns S., van Dam T.J., Alhashem A., Tabarki B.,
RA   Lu Q., Lambacher N.J., Kennedy J.E., Bowie R.V., Hetterschijt L.,
RA   van Beersum S., van Reeuwijk J., Boldt K., Kremer H., Kesterson R.A.,
RA   Monies D., Abouelhoda M., Roepman R., Huynen M.H., Ueffing M.,
RA   Russell R.B., Wolfrum U., Yoder B.K., van Wijk E., Alkuraya F.S.,
RA   Blacque O.E.;
RT   "KIAA0556 is a novel ciliary basal body component mutated in Joubert
RT   syndrome.";
RL   Genome Biol. 16:R293.1-R293.23(2015).
CC   -!- FUNCTION: May regulate ciliary A-tubule number and, along with arl-13,
CC       controls cilium integrity. {ECO:0000269|PubMed:26714646}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:26714646}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000269|PubMed:26714646}. Note=Accumulates at the ciliary
CC       base, proximal to the transition zone, and within the proximal ciliary
CC       axoneme (middle segment and transition zone) (PubMed:26714646). Does
CC       not undergo processive movement within the ciliary axonemes or the
CC       neuronal processes (PubMed:26714646). {ECO:0000269|PubMed:26714646}.
CC   -!- TISSUE SPECIFICITY: Expressed in most ciliated neuronal cells
CC       (PubMed:26714646). Not expressed in non-ciliated cells
CC       (PubMed:26714646). {ECO:0000269|PubMed:26714646}.
CC   -!- DISRUPTION PHENOTYPE: No obvious phenotype. Ultrastructural analyses
CC       reveal disruption of ciliary microtubule load and organization,
CC       although various aspects of gross cilium length, function and transport
CC       are mostly normal. {ECO:0000269|PubMed:26714646}.
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DR   EMBL; BX284601; CCD70034.2; -; Genomic_DNA.
DR   PIR; B87804; B87804.
DR   RefSeq; NP_491836.2; NM_059435.2.
DR   AlphaFoldDB; O44770; -.
DR   IntAct; O44770; 3.
DR   STRING; 6239.K04F10.2; -.
DR   PaxDb; O44770; -.
DR   EnsemblMetazoa; K04F10.2.1; K04F10.2.1; WBGene00019395.
DR   UCSC; K04F10.2; c. elegans.
DR   WormBase; K04F10.2; CE53694; WBGene00019395; -.
DR   eggNOG; ENOG502QRY1; Eukaryota.
DR   GeneTree; ENSGT00390000004566; -.
DR   HOGENOM; CLU_003418_2_1_1; -.
DR   InParanoid; O44770; -.
DR   OrthoDB; 361541at2759; -.
DR   PhylomeDB; O44770; -.
DR   PRO; PR:O44770; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00019395; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   InterPro; IPR026704; KATNIP.
DR   InterPro; IPR027859; KATNIP_dom.
DR   PANTHER; PTHR21534; PTHR21534; 1.
DR   Pfam; PF14652; DUF4457; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..568
FT                   /note="Protein KATNIP homolog"
FT                   /id="PRO_0000436066"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  64116 MW;  38116BD0BC291193 CRC64;
     MSDSDLKEIE KNAENIKLEP AEDEVNEEDQ NEITIPELPE GRVLELRLLS NWGDSHYIGL
     NSVEIFTSTG ERAVIDKVTT NVTEYTGSLE SLIVQRVHCK DAEKMWCAKT TEEKIVLTLE
     LKETCKLALI RFWNYNASRV HAQIGVRYLE MYLDGVGIFR GELECAFSAD SEFTPVMGET
     VLFTTSDNIL ELIALHDVCL ISLPEEPISN SSIEMLKADH LTPYRPSTCE AKDAPSTPVT
     IVPPPIFRQT GTAYKHDVKT LHIELLSNWG MDGLIGLTGL ELVDEHSQLI DESQYTVTTS
     DGNSDLSKKL FNGRNLTRDP HDMWLVDFDS KNFTTISITF HDNVALKAIS VWNYNASFEL
     SYAGVKAAKI YINGKLIKNV LLRKATGFVY FDYVQDVVLD PNNTERDFVP KGISQSIGGF
     VFQIRLLSTW GDEFYIGLNG IELYNRKGEL MKIREHNLAA FPESVNILPN IKNDLRTSNN
     LITQPNDTDI ARNMWLTALL PNRCARVFFV FDVQTYISKI VIYNYRKTPE RGVRHISVTV
     DDLIIFSGEI PSSTATLTGN LEINLMDI