KATIP_MOUSE
ID KATIP_MOUSE Reviewed; 1610 AA.
AC Q8C753; Q80TX9; Q8C759; Q8CFE1; Q8K0N9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Katanin-interacting protein;
GN Name=Katnip; Synonyms=Kiaa0556;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 513-1610 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 144-558 AND 898-1610 (ISOFORM 1).
RC TISSUE=Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1081-1610 (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=26714646; DOI=10.1186/s13059-015-0858-z;
RA Sanders A.A., de Vrieze E., Alazami A.M., Alzahrani F., Malarkey E.B.,
RA Sorusch N., Tebbe L., Kuhns S., van Dam T.J., Alhashem A., Tabarki B.,
RA Lu Q., Lambacher N.J., Kennedy J.E., Bowie R.V., Hetterschijt L.,
RA van Beersum S., van Reeuwijk J., Boldt K., Kremer H., Kesterson R.A.,
RA Monies D., Abouelhoda M., Roepman R., Huynen M.H., Ueffing M.,
RA Russell R.B., Wolfrum U., Yoder B.K., van Wijk E., Alkuraya F.S.,
RA Blacque O.E.;
RT "KIAA0556 is a novel ciliary basal body component mutated in Joubert
RT syndrome.";
RL Genome Biol. 16:R293.1-R293.23(2015).
CC -!- FUNCTION: May influence the stability of microtubules (MT), possibly
CC through interaction with the MT-severing katanin complex.
CC {ECO:0000250|UniProtKB:O60303}.
CC -!- SUBUNIT: Interacts with microtubules. Interacts with 4 subunits of the
CC katanin complex: KATNA1, KATNAL1, KATNB1 and KATNBL1.
CC {ECO:0000250|UniProtKB:O60303}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:O60303}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:O60303}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:O60303}. Note=When overexpressed, localizes to
CC the cytoplasm where it associates with acetylated alpha-tubulin.
CC {ECO:0000250|UniProtKB:O60303}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8C753-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C753-2; Sequence=VSP_030009, VSP_030011, VSP_030012;
CC Name=3;
CC IsoId=Q8C753-3; Sequence=VSP_030010;
CC Name=4;
CC IsoId=Q8C753-4; Sequence=VSP_030013;
CC -!- DISRUPTION PHENOTYPE: Knockout mice frequently display brain-specific
CC defects, resulting in a noncommunicating (obstructive) hydrocephalus.
CC {ECO:0000269|PubMed:26714646}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30902.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH42743.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK052492; BAC35016.1; -; mRNA.
DR EMBL; AK052528; BAC35027.1; -; mRNA.
DR EMBL; BC030902; AAH30902.1; ALT_INIT; mRNA.
DR EMBL; BC042743; AAH42743.1; ALT_INIT; mRNA.
DR EMBL; AK122309; BAC65591.3; -; Transcribed_RNA.
DR CCDS; CCDS40123.1; -. [Q8C753-1]
DR RefSeq; NP_001074491.1; NM_001081022.1. [Q8C753-1]
DR AlphaFoldDB; Q8C753; -.
DR BioGRID; 231458; 2.
DR STRING; 10090.ENSMUSP00000065744; -.
DR iPTMnet; Q8C753; -.
DR PhosphoSitePlus; Q8C753; -.
DR MaxQB; Q8C753; -.
DR PaxDb; Q8C753; -.
DR PRIDE; Q8C753; -.
DR Antibodypedia; 26294; 29 antibodies from 10 providers.
DR Ensembl; ENSMUST00000069660; ENSMUSP00000065744; ENSMUSG00000032743. [Q8C753-1]
DR GeneID; 233865; -.
DR KEGG; mmu:233865; -.
DR UCSC; uc009jqm.1; mouse. [Q8C753-1]
DR UCSC; uc009jqn.1; mouse. [Q8C753-2]
DR CTD; 23247; -.
DR MGI; MGI:2442760; Katnip.
DR VEuPathDB; HostDB:ENSMUSG00000032743; -.
DR eggNOG; ENOG502QRY1; Eukaryota.
DR GeneTree; ENSGT00390000004566; -.
DR HOGENOM; CLU_003418_0_1_1; -.
DR InParanoid; Q8C753; -.
DR OMA; QKPPWLA; -.
DR OrthoDB; 361541at2759; -.
DR PhylomeDB; Q8C753; -.
DR TreeFam; TF314150; -.
DR BioGRID-ORCS; 233865; 2 hits in 72 CRISPR screens.
DR ChiTaRS; D430042O09Rik; mouse.
DR PRO; PR:Q8C753; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C753; protein.
DR Bgee; ENSMUSG00000032743; Expressed in retinal neural layer and 217 other tissues.
DR ExpressionAtlas; Q8C753; baseline and differential.
DR Genevisible; Q8C753; MM.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IMP:MGI.
DR InterPro; IPR026704; KATNIP.
DR InterPro; IPR027859; KATNIP_dom.
DR PANTHER; PTHR21534; PTHR21534; 1.
DR Pfam; PF14652; DUF4457; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Coiled coil; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..1610
FT /note="Katanin-interacting protein"
FT /id="PRO_0000313091"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 330..354
FT /evidence="ECO:0000255"
FT COMPBIAS 84..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..215
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..809
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 658
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O60303"
FT MOD_RES 688
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O60303"
FT VAR_SEQ 1..260
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030009"
FT VAR_SEQ 738..870
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030010"
FT VAR_SEQ 1262..1278
FT /note="LIDGMNITTEDEHMWLI -> CPFTVALSPAGTDCLGS (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030011"
FT VAR_SEQ 1280..1610
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030012"
FT VAR_SEQ 1476..1508
FT /note="NRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFG -> PKLPTLQRSLGLGRV
FT WEAGRVRGAGLTGAGPTLSQ (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_030013"
FT CONFLICT 144..147
FT /note="EAGS -> HASA (in Ref. 3; AAH42743)"
FT /evidence="ECO:0000305"
FT CONFLICT 513..533
FT /note="VDIRNAVLPGELGCLVNRDLV -> GPFALKTGRNVSNSSHPLAFQ (in
FT Ref. 2; BAC35016)"
FT /evidence="ECO:0000305"
FT CONFLICT 549..558
FT /note="LQLYFIIHNM -> PLSLPFDVLH (in Ref. 3; AAH42743)"
FT /evidence="ECO:0000305"
FT CONFLICT 1093
FT /note="E -> Q (in Ref. 4; BAC65591)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1610 AA; 179609 MW; C48BE0ACA94B0149 CRC64;
MDGQALRKVE RSRSCSQERK EGYSKDMVTD FDEKHDEYLI LLQQRNRILK HLKAKDPVQL
RLEHLEQGFS VYVNGANSEL KTSPRKAVHT DFSRSASQAE GSQDYGRRTL FREAEEVLRR
SSRTAPGKVQ RRGWHQKSVQ IRTEAGSRLH IEPPLDCSED FESQEDVIGK HEDATGEHTQ
ELRKGLGLST SLQTQEDGSS DEYDSIEEDV LSETETEDPV LPVHNRDECP LPSHDAVQKD
VPKDQELEGR HPQATDTLVV MEFNPASKGN KMDRILSAKR KENAEVFIPS KPDSVLNPQP
PAVFPEQERA CSRSGSRRDR PLSATRKAYA AEDREEDASA VLKAIQVENE ALQQVFLSHD
PELHTSPQQD TKEPPAKSWS SLLKAKEDIP ELLPATPVTT DPELCRAAAG AKAVSQAMDG
MSPLGSRQQH KLVGVLQTME SDTTHLSQVA IPTEKPVPNS EEKWKARVDE IEDAIYVTME
ILSNWGNASW VGLTEVQFFD LNNIKLYVSP HDVDIRNAVL PGELGCLVNR DLVSKKDPPV
WTCPFHPPLQ LYFIIHNMRQ LRDFGLTMIK VRNYWTADGD LDIGAKNVKL YVNKSLIFDG
VLEKGGGEAP SDCTIPVDLQ RERNESSDKA LSTGWKESKG ALKMAALSDA RELGLSCSQP
AESLDMTVSS QGDFLGEKVN STSGLKNSLS KLQEDVRLLA TPASMGDGPS VPSSSSPGKC
LPLEEEPSLI QQLESLRGRK IPEPTGKTPH WLQPSLAGMG KKQTVRKPKP LWLSPEKDLE
QKSRFPSEDV MGDTPGEVET REKGPRREQG RTSSWNVITE ERAPKAFSKA CGDDLDIFSQ
LPNRDRPASG RRALKKEASS SHGDDRPASK EDTQASQTLP WLQWYGEQEH ALHASWDSLT
AFDRAHRGRI SALEPQGDIL DEFLKQQRSS RHEEFPAPCR EEEPEPSTEM GGDSDFKIPV
LPYGQHLVID IKSTWGDRHY VGLNGIEIFS SSGEPVQISS ITADPPDINI LPAYGKDPRV
VSNLIDGVNR TQDDMHVWLA PFTPGMTHTI SIEFTHPCQV ALIRIWNYNK SRIHSFRGVK
DITMLLDTQC IFEGEIAKAS GTLMGAPEHF GDTILFTMDE DILEAIFCLD DTFDMDAESL
CGLQPEEALR RPSTADGEGQ DERPFTQAGL GAQDQVPGLE LQTSPPVSEV TTPEPGIFYG
LCLRLNLTAS WGDLHYIGLT GLEVVGKDGE ALPIQPHQLS ASPRDLNDLP EYNDDSRTLD
KLIDGMNITT EDEHMWLIPF SPGLDHVVMI HFDRAQSIAG LRLWNYNKSP EDTYRGVKIA
HVSLDGLCVS PAEGFLIRKG PGNCHFDFAQ EILFGDYLQT RLPPAPTRRL DAKSLERASM
DYEAPLMPCG FIFQFQLLSS WGDPYYIGLT GLELYDEHGE RIPLSQNNIA AFPDSVNALE
GVCGDVRTPD KLIDQVNDTS DGRHMWLAPI LPGLVNRVYV IFDLPTTVSM IKLWNYTKTP
QRGVKEFGLL VDDLLVYNGI LAMVSHLVGG ILPTCEPTVP HHTILFAEDT DFCHQEKHAI
ISKPEEDQDI QMMNENQVIT TSRRKPGTAD PALRPKTCIR EKETSRRWRC
