KAX1F_MESMA
ID KAX1F_MESMA Reviewed; 57 AA.
AC H2ER23;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 25-MAY-2022, entry version 23.
DE RecName: Full=Potassium channel toxin alpha-KTx 1.15;
DE AltName: Full=BmKcug2 {ECO:0000303|PubMed:22230549};
DE Short=Kcug1 {ECO:0000312|EMBL:AEX92700.1, ECO:0000312|EMBL:AEX92703.1};
DE Flags: Precursor;
OS Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX NCBI_TaxID=34649;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND NOMENCLATURE.
RC TISSUE=Venom gland;
RX PubMed=22230549; DOI=10.1016/j.peptides.2011.12.012;
RA Zeng X.C., Zhang L., Nie Y., Luo X.;
RT "Identification and molecular characterization of three new K(+)-channel
RT specific toxins from the Chinese scorpion Mesobuthus martensii Karsch
RT revealing intronic number polymorphism and alternative splicing in
RT duplicated genes.";
RL Peptides 34:311-323(2012).
CC -!- FUNCTION: Potent blocker of both large-conductance calcium-activated
CC potassium channels (KCa1.1/KCNMA1) and voltage-gated potassium channels
CC (Kv1.3/KCNA3). {ECO:0000250|UniProtKB:Q9NII6}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9NII6}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC beta-sheet by disulfide bonds (CSalpha/beta).
CC {ECO:0000250|UniProtKB:Q9NII6}.
CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC channel inhibitor family. Alpha-KTx 01 subfamily. {ECO:0000305}.
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DR EMBL; JQ023129; AEX92700.1; -; Genomic_DNA.
DR EMBL; JQ074235; AEX92703.1; -; mRNA.
DR AlphaFoldDB; H2ER23; -.
DR SMR; H2ER23; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR Pfam; PF00451; Toxin_2; 1.
DR PRINTS; PR00286; CHARYBDTOXIN.
DR SUPFAM; SSF57095; SSF57095; 1.
DR PROSITE; PS01138; SCORP_SHORT_TOXIN; 1.
PE 3: Inferred from homology;
KW Calcium-activated potassium channel impairing toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW Pyrrolidone carboxylic acid; Secreted; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000250|UniProtKB:Q9NII6"
FT CHAIN 21..57
FT /note="Potassium channel toxin alpha-KTx 1.15"
FT /id="PRO_0000417435"
FT SITE 47
FT /note="Basic residue of the functional dyad"
FT /evidence="ECO:0000250"
FT SITE 56
FT /note="Aromatic residue of the functional dyad"
FT /evidence="ECO:0000250"
FT MOD_RES 21
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:Q9NII6"
FT DISULFID 27..48
FT /evidence="ECO:0000250|UniProtKB:Q9NII6"
FT DISULFID 33..53
FT /evidence="ECO:0000250|UniProtKB:Q9NII6"
FT DISULFID 37..55
FT /evidence="ECO:0000250|UniProtKB:Q9NII6"
SQ SEQUENCE 57 AA; 6370 MW; 78C2184CE8ABDCDB CRC64;
MKISFLLLAL VICSIGWSEA QFTDVKCTAS KQCWPVCNQM FGKPNGKCMN GKCRCYS
