ID   KAX26_CENLM             Reviewed;          34 AA.
AC   P59849;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2003, sequence version 1.
DT   23-FEB-2022, entry version 52.
DE   RecName: Full=Potassium channel toxin alpha-KTx 2.6;
DE   AltName: Full=Hongotoxin-3 {ECO:0000303|PubMed:9446567};
DE            Short=HgTX3 {ECO:0000303|PubMed:9446567};
DE   Flags: Fragment;
OS   Centruroides limbatus (Bark scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides.
OX   NCBI_TaxID=244936;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=9446567; DOI=10.1074/jbc.273.5.2639;
RA   Koschak A., Bugianesi R.M., Mitterdorfer J., Kaczorowski G.J., Garcia M.L.,
RA   Knaus H.-G.;
RT   "Subunit composition of brain voltage-gated potassium channels determined
RT   by hongotoxin-1, a novel peptide derived from Centruroides limbatus
RT   venom.";
RL   J. Biol. Chem. 273:2639-2644(1998).
CC   -!- FUNCTION: Potent inhibitor of Kv1/KCNA voltage-gated potassium
CC       channels. {ECO:0000250|UniProtKB:P59847}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9446567}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:9446567}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000250|UniProtKB:P40755}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 02 subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR   Pfam; PF00451; Toxin_2; 1.
DR   PRINTS; PR00286; CHARYBDTOXIN.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   CHAIN           1..>34
FT                   /note="Potassium channel toxin alpha-KTx 2.6"
FT                   /id="PRO_0000066834"
FT   SITE            27
FT                   /note="Basic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   NON_TER         34
SQ   SEQUENCE   34 AA;  3647 MW;  2FFA1C22D0015784 CRC64;
     TFINVKCTSP KQCLPACKEK FGXAAGKCMN GKCK