ID   KAX2I_CENLI             Reviewed;          39 AA.
AC   P0DL70;
DT   05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Potassium channel toxin alpha-KTx 2.18 {ECO:0000303|PubMed:27889600};
DE   AltName: Full=CllTx5 {ECO:0000303|PubMed:27889600};
OS   Centruroides limpidus (Mexican scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides.
OX   NCBI_TaxID=6876;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=27889600; DOI=10.1016/j.toxicon.2016.11.256;
RA   Cid Uribe J.I., Jimenez Vargas J.M., Ferreira Batista C.V.,
RA   Zamudio Zuniga F., Possani L.D.;
RT   "Comparative proteomic analysis of female and male venoms from the Mexican
RT   scorpion Centruroides limpidus: novel components found.";
RL   Toxicon 125:91-98(2017).
CC   -!- FUNCTION: Weakly blocks Kv1.3/KCNA3 voltage-gated potassium channels.
CC       {ECO:0000250|UniProtKB:P0C165}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27889600}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:27889600}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: This toxin is only found in female specimens.
CC       {ECO:0000269|PubMed:27889600}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 02 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0DL70; -.
DR   SMR; P0DL70; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR   Pfam; PF00451; Toxin_2; 1.
DR   PRINTS; PR00286; CHARYBDTOXIN.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Toxin; Voltage-gated potassium channel impairing toxin.
FT   CHAIN           1..39
FT                   /note="Potassium channel toxin alpha-KTx 2.18"
FT                   /evidence="ECO:0000269|PubMed:27889600"
FT                   /id="PRO_0000440865"
FT   SITE            28
FT                   /note="Basic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         39
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P0C165"
FT   DISULFID        7..29
FT                   /evidence="ECO:0000250|UniProtKB:P40755"
FT   DISULFID        13..34
FT                   /evidence="ECO:0000250|UniProtKB:P40755"
FT   DISULFID        17..36
FT                   /evidence="ECO:0000250|UniProtKB:P40755"
SQ   SEQUENCE   39 AA;  4232 MW;  646B84AE3939901E CRC64;
     TTINVKCTSP KQCLPPCKEI YGRHAGAKCI NGKCHCSKI