ID   KAX2Y_CENLM             Reviewed;          23 AA.
AC   P59850;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2003, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Hongotoxin-4 {ECO:0000303|PubMed:9446567};
DE            Short=HgTX4 {ECO:0000303|PubMed:9446567};
DE   AltName: Full=Potassium channel toxin alpha-KTx 02 {ECO:0000305};
DE   Flags: Fragment;
OS   Centruroides limbatus (Bark scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides.
OX   NCBI_TaxID=244936;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RX   PubMed=9446567; DOI=10.1074/jbc.273.5.2639;
RA   Koschak A., Bugianesi R.M., Mitterdorfer J., Kaczorowski G.J., Garcia M.L.,
RA   Knaus H.-G.;
RT   "Subunit composition of brain voltage-gated potassium channels determined
RT   by hongotoxin-1, a novel peptide derived from Centruroides limbatus
RT   venom.";
RL   J. Biol. Chem. 273:2639-2644(1998).
CC   -!- FUNCTION: Potent selective inhibitor of Kv1/KCNA voltage-gated
CC       potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9446567}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:9446567}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 02 subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P59850; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR   Pfam; PF00451; Toxin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   CHAIN           1..>23
FT                   /note="Hongotoxin-4"
FT                   /id="PRO_0000066835"
FT   NON_TER         23
SQ   SEQUENCE   23 AA;  2506 MW;  46EDC2CC38425272 CRC64;
     KVIDVKCTSP KQCLPPCKAQ FGD