ID   KAX3F_MESGB             Reviewed;          29 AA.
AC   B3EWY0;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 1.
DT   23-FEB-2022, entry version 22.
DE   RecName: Full=Potassium channel toxin alpha-KTx 3.15 {ECO:0000250|UniProtKB:P0C909};
DE   AltName: Full=MegKTx1 {ECO:0000303|PubMed:23142506};
DE   Flags: Fragment;
OS   Mesobuthus gibbosus (Mediterranean checkered scorpion) (Buthus gibbosus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=123226;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom {ECO:0000269|PubMed:23142506};
RX   PubMed=23142506; DOI=10.1016/j.toxicon.2012.10.010;
RA   Diego-Garcia E., Peigneur S., Debaveye S., Gheldof E., Tytgat J.,
RA   Caliskan F.;
RT   "Novel potassium channel blocker venom peptides from Mesobuthus gibbosus
RT   (Scorpiones: Buthidae).";
RL   Toxicon 61:72-82(2013).
CC   -!- FUNCTION: May play a role in blocking voltage-gated potassium channels
CC       Kv1.1/KCNA1, Kv1.3/KCNA3 and Kv1.6/KCNA6.
CC       {ECO:0000269|PubMed:23142506}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23142506}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:23142506}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: Has no effect on rat Kv1.2/KCNA2, Kv1.4/KCNA4 and
CC       Kv1.5/KCNA5 channels. {ECO:0000305|PubMed:23142506}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 03 subfamily. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..29
FT                   /note="Potassium channel toxin alpha-KTx 3.15"
FT                   /evidence="ECO:0000269|PubMed:23142506"
FT                   /id="PRO_0000421236"
FT   DISULFID        8..27
FT                   /evidence="ECO:0000250|UniProtKB:P55896"
FT   NON_TER         29
FT                   /evidence="ECO:0000303|PubMed:23142506"
SQ   SEQUENCE   29 AA;  3201 MW;  CB4F1D673547ED99 CRC64;
     GSPLTYPCHS AQCEQPCKDA NMRFGXCMN