KAX67_OPICA
ID KAX67_OPICA Reviewed; 61 AA.
AC Q6XLL8;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Potassium channel toxin alpha-KTx 6.7 {ECO:0000303|PubMed:14696198};
DE AltName: Full=OcKTx2 {ECO:0000303|PubMed:14696198};
DE Flags: Precursor;
OS Opistophthalmus carinatus (African yellow leg scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Opistophthalminae;
OC Opistophthalmus.
OX NCBI_TaxID=190115;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=14696198; DOI=10.1002/prot.10588;
RA Zhu S.-Y., Huys I., Dyason K., Verdonck F., Tytgat J.;
RT "Evolutionary trace analysis of scorpion toxins specific for K-channels.";
RL Proteins 54:361-370(2004).
CC -!- FUNCTION: Blocker of voltage-gated potassium channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC channel inhibitor family. Alpha-KTx 06 subfamily. {ECO:0000305}.
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DR EMBL; AY225780; AAP73818.1; -; mRNA.
DR AlphaFoldDB; Q6XLL8; -.
DR SMR; Q6XLL8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR Pfam; PF00451; Toxin_2; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
DR PROSITE; PS01138; SCORP_SHORT_TOXIN; 1.
PE 2: Evidence at transcript level;
KW Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..60
FT /note="Potassium channel toxin alpha-KTx 6.7"
FT /id="PRO_0000227032"
FT MOD_RES 60
FT /note="Cysteine amide"
FT /evidence="ECO:0000250|UniProtKB:Q10726"
FT DISULFID 29..50
FT /evidence="ECO:0000250|UniProtKB:Q10726"
FT DISULFID 35..55
FT /evidence="ECO:0000250|UniProtKB:Q10726"
FT DISULFID 39..57
FT /evidence="ECO:0000250|UniProtKB:Q10726"
FT DISULFID 45..60
FT /evidence="ECO:0000250|UniProtKB:Q10726"
SQ SEQUENCE 61 AA; 6756 MW; BCA24D92D4F78615 CRC64;
MNAKFILLLL VVTTTMLLPD TQGAEVIKCR TPKDCADPCR KQTGCPHGKC MNRTCRCNRC
G