ID   KAX6G_OPICY             Reviewed;          67 AA.
AC   C5J896;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Potassium channel toxin alpha-KTx 6.16;
DE   AltName: Full=OcyC12 {ECO:0000303|PubMed:19379768};
DE   Flags: Precursor;
OS   Opisthacanthus cayaporum (South American scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Hemiscorpiidae; Opisthacanthus.
OX   NCBI_TaxID=573324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19379768; DOI=10.1016/j.toxicon.2009.04.010;
RA   Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P.,
RA   Possani L.D., Schwartz E.F.;
RT   "Cloning and characterization of cDNA sequences encoding for new venom
RT   peptides of the Brazilian scorpion Opisthacanthus cayaporum.";
RL   Toxicon 54:252-261(2009).
CC   -!- FUNCTION: Inhibits voltage-gated potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 06 subfamily. {ECO:0000305}.
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DR   EMBL; FM998754; CAX51400.1; -; mRNA.
DR   AlphaFoldDB; C5J896; -.
DR   SMR; C5J896; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..67
FT                   /note="Potassium channel toxin alpha-KTx 6.16"
FT                   /id="PRO_0000398609"
FT   DISULFID        34..55
FT                   /evidence="ECO:0000250|UniProtKB:Q10726"
FT   DISULFID        40..60
FT                   /evidence="ECO:0000250|UniProtKB:Q10726"
FT   DISULFID        44..62
FT                   /evidence="ECO:0000250|UniProtKB:Q10726"
FT   DISULFID        50..65
FT                   /evidence="ECO:0000250|UniProtKB:Q10726"
SQ   SEQUENCE   67 AA;  7560 MW;  23ABD0E1A00BEA75 CRC64;
     MNLKLALVLL LTVINVGMLP GATSNGNIKT DIKCYRNSHC NFHCEKSYYC QGSKCVRKRC
     NCYNCPL