ID   KAX6X_OPICY             Reviewed;          14 AA.
AC   P86105;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   23-FEB-2022, entry version 20.
DE   RecName: Full=Potassium channel toxin alpha-KTx 6 OcyKTx4;
DE   Flags: Fragment;
OS   Opisthacanthus cayaporum (South American scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Hemiscorpiidae; Opisthacanthus.
OX   NCBI_TaxID=573324;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=18502464; DOI=10.1016/j.toxicon.2008.03.029;
RA   Schwartz E.F., Camargos T.S., Zamudio F.Z., Silva L.P., Bloch C. Jr.,
RA   Caixeta F., Schwartz C.A., Possani L.D.;
RT   "Mass spectrometry analysis, amino acid sequence and biological activity of
RT   venom components from the Brazilian scorpion Opisthacanthus cayaporum.";
RL   Toxicon 51:1499-1508(2008).
CC   -!- FUNCTION: Blocks voltage-gated potassium channels.
CC       {ECO:0000250|UniProtKB:P58498}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18502464}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:18502464}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3773.0; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18502464};
CC   -!- MISCELLANEOUS: This peptide elutes at 19.98 min.
CC       {ECO:0000305|PubMed:18502464}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 06 subfamily. {ECO:0000255}.
CC   -!- CAUTION: Ser-13 may be erroneous, since homologs contain a Cys at this
CC       position. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..>14
FT                   /note="Potassium channel toxin alpha-KTx 6 OcyKTx4"
FT                   /evidence="ECO:0000305|PubMed:18502464"
FT                   /id="PRO_0000398132"
FT   DISULFID        3..?
FT                   /evidence="ECO:0000250|UniProtKB:Q10726"
FT   DISULFID        9..?
FT                   /evidence="ECO:0000250|UniProtKB:Q10726"
FT   NON_TER         14
FT                   /evidence="ECO:0000303|PubMed:18502464"
SQ   SEQUENCE   14 AA;  1594 MW;  4ACD7C23639E9613 CRC64;
     IRCTGSKECY SPSY