KAX6Y_OPICY
ID KAX6Y_OPICY Reviewed; 24 AA.
AC P86106;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 25-MAY-2022, entry version 28.
DE RecName: Full=Potassium channel toxin alpha-KTx 6 OcyKTx5;
DE Flags: Fragment;
OS Opisthacanthus cayaporum (South American scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Iurida; Scorpionoidea; Hemiscorpiidae; Opisthacanthus.
OX NCBI_TaxID=573324;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Venom;
RX PubMed=18502464; DOI=10.1016/j.toxicon.2008.03.029;
RA Schwartz E.F., Camargos T.S., Zamudio F.Z., Silva L.P., Bloch C. Jr.,
RA Caixeta F., Schwartz C.A., Possani L.D.;
RT "Mass spectrometry analysis, amino acid sequence and biological activity of
RT venom components from the Brazilian scorpion Opisthacanthus cayaporum.";
RL Toxicon 51:1499-1508(2008).
CC -!- FUNCTION: Blocks voltage-gated potassium channels.
CC {ECO:0000250|UniProtKB:P58498}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18502464}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000269|PubMed:18502464}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: This peptide elutes at 21.22 min. and comes from a
CC fraction that contains 2 components (PubMed:18502464).
CC {ECO:0000305|PubMed:18502464}.
CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC channel inhibitor family. Alpha-KTx 06 subfamily. {ECO:0000255}.
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DR AlphaFoldDB; P86106; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR Pfam; PF00451; Toxin_2; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Potassium channel impairing toxin; Secreted; Toxin.
FT PEPTIDE 1..>24
FT /note="Potassium channel toxin alpha-KTx 6 OcyKTx5"
FT /evidence="ECO:0000305|PubMed:18502464"
FT /id="PRO_0000398133"
FT DISULFID 3..24
FT /evidence="ECO:0000250|UniProtKB:P58498"
FT DISULFID 9..?
FT /evidence="ECO:0000250|UniProtKB:P58498"
FT DISULFID 13..?
FT /evidence="ECO:0000250|UniProtKB:P58498"
FT DISULFID 19..?
FT /evidence="ECO:0000250|UniProtKB:P58498"
FT NON_TER 24
FT /evidence="ECO:0000303|PubMed:18502464"
SQ SEQUENCE 24 AA; 2584 MW; 0DB7679EBD1A307A CRC64;
IRCTGSKECY SPCYKATGCP NAKC