ID   KAX84_LEIHE             Reviewed;          29 AA.
AC   P80671;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Potassium channel toxin alpha-KTx 8.4 {ECO:0000305};
DE   AltName: Full=Leiuropeptide III {ECO:0000303|PubMed:9266482};
DE            Short=LpIII;
DE   AltName: Full=Leiuropeptide-3 {ECO:0000305};
OS   Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus
OS   hebraeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Leiurus.
OX   NCBI_TaxID=6884;
RN   [1]
RP   PROTEIN SEQUENCE, STRUCTURE BY NMR, AND DISULFIDE BONDS.
RC   TISSUE=Venom;
RX   PubMed=9266482; DOI=10.1111/j.1399-3011.1997.tb01162.x;
RA   Buisine E., Wieruszeski J.-M., Lippens G., Wouters D., Tartar A.,
RA   Sautiere P.;
RT   "Characterization of a new family of toxin-like peptides from the venom of
RT   the scorpion Leiurus quinquestriatus hebraeus. 1H-NMR structure of
RT   leiuropeptide II.";
RL   J. Pept. Res. 49:545-555(1997).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=16551474; DOI=10.1016/j.toxicon.2006.01.015;
RA   Nascimento D.G., Rates B., Santos D.M., Verano-Braga T., Barbosa-Silva A.,
RA   Dutra A.A.A., Biondi I., Martin-Eauclaire M.-F., De Lima M.E.,
RA   Pimenta A.M.C.;
RT   "Moving pieces in a taxonomic puzzle: venom 2D-LC/MS and data clustering
RT   analyses to infer phylogenetic relationships in some scorpions from the
RT   Buthidae family (Scorpiones).";
RL   Toxicon 47:628-639(2006).
CC   -!- FUNCTION: Inhibits voltage-gated potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000269|PubMed:9266482}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 08 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P80671; -.
DR   SMR; P80671; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..29
FT                   /note="Potassium channel toxin alpha-KTx 8.4"
FT                   /id="PRO_0000044543"
FT   DISULFID        3..19
FT                   /evidence="ECO:0000269|PubMed:9266482"
FT   DISULFID        6..24
FT                   /evidence="ECO:0000269|PubMed:9266482"
FT   DISULFID        10..26
FT                   /evidence="ECO:0000269|PubMed:9266482"
SQ   SEQUENCE   29 AA;  3214 MW;  BF3F650C196C15B8 CRC64;
     VSCEDCPDHC STQKARAKCD NDKCVCEPK