KAX85_ODODO
ID KAX85_ODODO Reviewed; 57 AA.
AC P0CC12; A0A0U4I1L0;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Potassium channel toxin alpha-KTx 8.5 {ECO:0000305};
DE AltName: Full=OdK1 {ECO:0000303|PubMed:17070524};
DE AltName: Full=Potassium channel toxin KTx7 {ECO:0000312|EMBL:ALX72349.1};
DE Short=ODKTx7 {ECO:0000312|EMBL:ALX72349.1};
DE Flags: Precursor;
OS Odontobuthus doriae (Yellow Iranian scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Odontobuthus.
OX NCBI_TaxID=342590;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RA Soorki M.N., Galehdari H., Jalali A., Baradaran M.;
RT "First venom gland transcriptomic analysis of Iranian yellow scorpion
RT 'Odonthubuthus doriae'.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 29-57, FUNCTION, SUBCELLULAR LOCATION, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom;
RX PubMed=17070524; DOI=10.1016/j.febslet.2006.10.029;
RA Abdel-Mottaleb Y., Clynen E., Jalali A., Bosmans F., Vatanpour H.,
RA Schoofs L., Tytgat J.;
RT "The first potassium channel toxin from the venom of the Iranian scorpion
RT Odonthobuthus doriae.";
RL FEBS Lett. 580:6254-6258(2006).
CC -!- FUNCTION: Selectively inhibits voltage-gated potassium channels
CC Kv1.2/KCNA2 (IC(50)=183 nM). {ECO:0000269|PubMed:17070524}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17070524}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:17070524}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC beta-sheet by disulfide bonds (CSalpha/beta).
CC {ECO:0000250|UniProtKB:P80671}.
CC -!- MASS SPECTROMETRY: Mass=3180.12; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:17070524};
CC -!- MISCELLANEOUS: This toxin does not affect Kv1.1/KCNA1, Kv1.3/KCNA3,
CC Kv1.4/KCNA4, Kv1.5/KCNA5 and Shaker IR. {ECO:0000305|PubMed:17070524}.
CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC channel inhibitor family. Alpha-KTx 08 subfamily. {ECO:0000305}.
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DR EMBL; KU365851; ALX72349.1; -; mRNA.
DR AlphaFoldDB; P0CC12; -.
DR SMR; P0CC12; -.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0019870; F:potassium channel inhibitor activity; IDA:UniProtKB.
DR GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR GO; GO:0044361; P:negative regulation of voltage-gated potassium channel activity in another organism; IDA:UniProtKB.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR Pfam; PF05453; Toxin_6; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL 1..28
FT /evidence="ECO:0000269|PubMed:17070524"
FT PEPTIDE 29..57
FT /note="Potassium channel toxin alpha-KTx 8.5"
FT /evidence="ECO:0000269|PubMed:17070524"
FT /id="PRO_0000390674"
FT DISULFID 31..47
FT /evidence="ECO:0000250|UniProtKB:P80671"
FT DISULFID 34..52
FT /evidence="ECO:0000250|UniProtKB:P80671"
FT DISULFID 38..54
FT /evidence="ECO:0000250|UniProtKB:P80671"
SQ SEQUENCE 57 AA; 6289 MW; 3C1DE8B38AB6340E CRC64;
MSRLYAIILI ALVLNVIMTI MPDSKVEAVS CEDCPEHCST QKARAKCDND KCVCESV
