ID   KAX87_MESEU             Reviewed;          57 AA.
AC   C0HJQ5; A0A088DAD0;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2015, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Potassium channel toxin alpha-KTx 8.7 {ECO:0000303|PubMed:25792741};
DE   AltName: Full=Toxin MeKTx1-2 {ECO:0000303|PubMed:25792741};
DE   Flags: Precursor;
OS   Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-57, MASS SPECTROMETRY,
RP   AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=25792741; DOI=10.1074/jbc.m115.637611;
RA   Kuzmenkov A.I., Vassilevski A.A., Kudryashova K.S., Nekrasova O.V.,
RA   Peigneur S., Tytgat J., Feofanov A.V., Kirpichnikov M.P., Grishin E.V.;
RT   "Variability of potassium channel blockers in Mesobuthus eupeus scorpion
RT   venom with focus on Kv1.1: an integrated transcriptomic and proteomic
RT   study.";
RL   J. Biol. Chem. 290:12195-12209(2015).
CC   -!- FUNCTION: Inhibits voltage-gated potassium channel rKv1.1/KCNA1 at
CC       nanomolar ranges (IC(50)=8.5 nM). {ECO:0000269|PubMed:25792741}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25792741}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:25792741}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000250|UniProtKB:Q9U8D2}.
CC   -!- MASS SPECTROMETRY: Mass=3232; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:25792741};
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 08 subfamily.
CC       {ECO:0000303|PubMed:25792741}.
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DR   EMBL; KF612500; AIL48758.1; -; mRNA.
DR   AlphaFoldDB; C0HJQ5; -.
DR   SMR; C0HJQ5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000269|PubMed:25792741"
FT   PEPTIDE         29..57
FT                   /note="Potassium channel toxin alpha-KTx 8.7"
FT                   /evidence="ECO:0000269|PubMed:25792741"
FT                   /id="PRO_0000433143"
FT   DISULFID        31..47
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8D2"
FT   DISULFID        34..52
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8D2"
FT   DISULFID        38..54
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8D2"
SQ   SEQUENCE   57 AA;  6417 MW;  A6F6109B620FA3E2 CRC64;
     MSRLYAIILI ALVFNVIMTI MPDMKVEAVS CEDCPPHCAT KDQRAKCEND KCVCEPK