ID   KAX8R_MESEU             Reviewed;          57 AA.
AC   E4VP43;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Potassium channel toxin MeuTXKalpha2 {ECO:0000303|PubMed:20889474};
DE   Flags: Precursor;
OS   Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20889474; DOI=10.1074/mcp.m110.002832;
RA   Zhu S., Peigneur S., Gao B., Luo L., Jin D., Zhao Y., Tytgat J.;
RT   "Molecular diversity and functional evolution of scorpion potassium channel
RT   toxins.";
RL   Mol. Cell. Proteomics 10:M110.002832-M110.002832(2011).
CC   -!- FUNCTION: Inhibits Kv1.1/KCNA1, Kv1.3/KCNA3 and Shaker potassium
CC       channels. {ECO:0000250|UniProtKB:P86400}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P86400}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:20889474}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000250|UniProtKB:Q9U8D2}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 08 subfamily. {ECO:0000255}.
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DR   EMBL; EF445085; ABR21060.1; -; mRNA.
DR   AlphaFoldDB; E4VP43; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..28
FT                   /evidence="ECO:0000250|UniProtKB:P86400"
FT                   /id="PRO_0000442924"
FT   PEPTIDE         29..57
FT                   /note="Potassium channel toxin MeuTXKalpha2"
FT                   /evidence="ECO:0000250|UniProtKB:P86400"
FT                   /id="PRO_5003191278"
FT   DISULFID        31..47
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8D2"
FT   DISULFID        34..52
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8D2"
FT   DISULFID        38..54
FT                   /evidence="ECO:0000250|UniProtKB:Q9U8D2"
SQ   SEQUENCE   57 AA;  6463 MW;  A6F7559B6214B562 CRC64;
     MSRLYAIILI ALVFNVIMTI MPDMKVEAVS CEDCPEHCAT KDQRAKCDND RCVCEPK