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KAX92_MESMA
ID   KAX92_MESMA             Reviewed;          56 AA.
AC   Q9U8D1;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Potassium channel toxin alpha-KTx 9.2 {ECO:0000305};
DE   AltName: Full=Neurotoxin BmP03 {ECO:0000303|PubMed:10471839};
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Venom gland;
RX   PubMed=10386622; DOI=10.1016/s0014-5793(99)00651-1;
RA   Wu J.-J., Dai L., Lan Z.-D., Chi C.-W.;
RT   "Genomic organization of three neurotoxins active on small conductance
RT   Ca2+-activated potassium channels from the scorpion Buthus martensi
RT   Karsch.";
RL   FEBS Lett. 452:360-364(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=10471839; DOI=10.1016/s0014-5793(99)01101-1;
RA   Zhu S.-Y., Li W.-X., Zeng X.-C., Jiang D.-H., Mao X., Liu H.;
RT   "Molecular cloning and sequencing of two 'short chain' and two 'long chain'
RT   K(+) channel-blocking peptides from the Chinese scorpion Buthus martensii
RT   Karsch.";
RL   FEBS Lett. 457:509-514(1999).
RN   [3]
RP   PROTEIN SEQUENCE OF 29-56, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RX   PubMed=9151979; DOI=10.1111/j.1432-1033.1997.00457.x;
RA   Romi-Lebrun R., Martin-Eauclaire M.-F., Escoubas P., Wu F.Q., Lebrun B.,
RA   Hisada M., Nakajima T.;
RT   "Characterization of four toxins from Buthus martensi scorpion venom, which
RT   act on apamin-sensitive Ca2+-activated K+ channels.";
RL   Eur. J. Biochem. 245:457-464(1997).
RN   [4]
RP   STRUCTURE BY NMR OF 29-56, AND DISULFIDE BONDS.
RA   He F., Li Y., Wu G., Cao C., Wu H.;
RT   "Three-dimensional structure of BmP03 from venom of scorpion Buthus
RT   martensii Karsch.";
RL   Acta Chim. Sin. 58:850-855(2000).
CC   -!- FUNCTION: Blocks small conductance calcium-activated potassium channels
CC       (KCNN, SK). Low toxicity by intracerebroventricular injection into
CC       mice.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9151979}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:9151979}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta). {ECO:0000269|Ref.4}.
CC   -!- MASS SPECTROMETRY: Mass=2935.29; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:9151979};
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 09 subfamily. {ECO:0000305}.
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DR   EMBL; AF097408; AAF01253.1; -; Genomic_DNA.
DR   EMBL; AF156170; AAF29463.1; -; mRNA.
DR   PDB; 1WM8; NMR; -; A=29-56.
DR   PDBsum; 1WM8; -.
DR   AlphaFoldDB; Q9U8D1; -.
DR   SMR; Q9U8D1; -.
DR   EvolutionaryTrace; Q9U8D1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Calcium-activated potassium channel impairing toxin;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000269|PubMed:9151979"
FT   PEPTIDE         29..56
FT                   /note="Potassium channel toxin alpha-KTx 9.2"
FT                   /evidence="ECO:0000269|PubMed:9151979"
FT                   /id="PRO_0000035350"
FT   DISULFID        31..47
FT                   /evidence="ECO:0000269|Ref.4, ECO:0000312|PDB:1WM8"
FT   DISULFID        34..52
FT                   /evidence="ECO:0000269|Ref.4, ECO:0000312|PDB:1WM8"
FT   DISULFID        38..54
FT                   /evidence="ECO:0000269|Ref.4, ECO:0000312|PDB:1WM8"
FT   HELIX           36..38
FT                   /evidence="ECO:0007829|PDB:1WM8"
FT   STRAND          40..42
FT                   /evidence="ECO:0007829|PDB:1WM8"
FT   STRAND          49..51
FT                   /evidence="ECO:0007829|PDB:1WM8"
SQ   SEQUENCE   56 AA;  6001 MW;  70953032007E8672 CRC64;
     MSRLFTLVLI VLAMNVMMAI ISDPVVEAVG CEECPMHCKG KNANPTCDDG VCNCNV
 
 
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