ID   KAX96_HOTJU             Reviewed;          28 AA.
AC   P83405;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Potassium channel toxin alpha-KTx 9.6 {ECO:0000305};
DE   AltName: Full=BjTx-1 {ECO:0000303|PubMed:15067003};
OS   Hottentotta judaicus (Black scorpion) (Buthotus judaicus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Hottentotta.
OX   NCBI_TaxID=6863;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=15067003; DOI=10.1074/jbc.m403284200;
RA   Zhu X., Zamudio F.Z., Olbinski B.A., Possani L.D., Valdivia H.H.;
RT   "Activation of skeletal ryanodine receptors by two novel scorpion toxins
RT   from Buthotus judaicus.";
RL   J. Biol. Chem. 279:26588-26596(2004).
CC   -!- FUNCTION: Calcium channel activator. Rapidly and reversibly activates
CC       ryanodine receptor 1 (RYR1). {ECO:0000269|PubMed:15067003}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15067003}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:15067003}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000250|UniProtKB:Q9NJP7}.
CC   -!- MASS SPECTROMETRY: Mass=2888.95; Mass_error=0.12; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15067003};
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 09 subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P83405; -.
DR   SMR; P83405; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005246; F:calcium channel regulator activity; IDA:UniProtKB.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR   GO; GO:0035916; P:modulation of calcium channel activity in another organism; IDA:UniProtKB.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin;
KW   Ryanodine-sensitive calcium-release channel impairing toxin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..28
FT                   /note="Potassium channel toxin alpha-KTx 9.6"
FT                   /evidence="ECO:0000269|PubMed:15067003"
FT                   /id="PRO_0000044946"
FT   DISULFID        3..19
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT   DISULFID        6..24
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT   DISULFID        10..26
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
SQ   SEQUENCE   28 AA;  2895 MW;  DD72AD78B48FFE15 CRC64;
     VGCEECPAHC KGKNAKPTCD DGVCNCNV