KAX97_HOTJU
ID KAX97_HOTJU Reviewed; 28 AA.
AC P83406;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Potassium channel toxin alpha-KTx 9.7 {ECO:0000305};
DE AltName: Full=BjTx-2 {ECO:0000303|PubMed:15067003};
OS Hottentotta judaicus (Black scorpion) (Buthotus judaicus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Hottentotta.
OX NCBI_TaxID=6863;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Venom;
RX PubMed=15067003; DOI=10.1074/jbc.m403284200;
RA Zhu X., Zamudio F.Z., Olbinski B.A., Possani L.D., Valdivia H.H.;
RT "Activation of skeletal ryanodine receptors by two novel scorpion toxins
RT from Buthotus judaicus.";
RL J. Biol. Chem. 279:26588-26596(2004).
CC -!- FUNCTION: Calcium channel activator. Rapidly and reversibly activates
CC ryanodine receptor 1 (RYR1). {ECO:0000269|PubMed:15067003}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15067003}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:15067003}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC beta-sheet by disulfide bonds (CSalpha/beta).
CC {ECO:0000250|UniProtKB:Q9NJP7}.
CC -!- MASS SPECTROMETRY: Mass=2874.46; Mass_error=0.37; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:15067003};
CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC channel inhibitor family. Alpha-KTx 09 subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P83406; -.
DR SMR; P83406; -.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005246; F:calcium channel regulator activity; IDA:UniProtKB.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR GO; GO:0035916; P:modulation of calcium channel activity in another organism; IDA:UniProtKB.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR Pfam; PF05453; Toxin_6; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin;
KW Ryanodine-sensitive calcium-release channel impairing toxin; Secreted;
KW Toxin.
FT PEPTIDE 1..28
FT /note="Potassium channel toxin alpha-KTx 9.7"
FT /evidence="ECO:0000269|PubMed:15067003"
FT /id="PRO_0000044947"
FT DISULFID 3..19
FT /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT DISULFID 6..24
FT /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT DISULFID 10..26
FT /evidence="ECO:0000250|UniProtKB:Q9NJP7"
SQ SEQUENCE 28 AA; 2880 MW; DD72AD78B605FE15 CRC64;
VGCEECPAHC KGKNAIPTCD DGVCNCNV