KAX98_BUTOS
ID KAX98_BUTOS Reviewed; 56 AA.
AC B8XH46;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=Potassium channel toxin alpha-KTx 9.8 {ECO:0000305};
DE AltName: Full=Toxin Tx784 {ECO:0000312|EMBL:ACJ23155.1};
DE Flags: Precursor;
OS Buthus occitanus israelis (Common yellow scorpion) (Buthus israelis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Buthus.
OX NCBI_TaxID=539894;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RA Zilberberg N., Kozminsky-Atias A.;
RT "Buthus occitanus israelis scorpion toxin.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potassium channel inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC beta-sheet by disulfide bonds (CSalpha/beta).
CC {ECO:0000250|UniProtKB:Q9NJP7}.
CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC channel inhibitor family. Alpha-KTx 09 subfamily. {ECO:0000305}.
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DR EMBL; FJ360835; ACJ23155.1; -; mRNA.
DR AlphaFoldDB; B8XH46; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR Pfam; PF05453; Toxin_6; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..28
FT /evidence="ECO:0000250"
FT /id="PRO_0000428961"
FT PEPTIDE 29..56
FT /note="Potassium channel toxin alpha-KTx 9.8"
FT /evidence="ECO:0000305|Ref.1"
FT /id="PRO_0000428962"
FT DISULFID 31..47
FT /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT DISULFID 34..52
FT /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT DISULFID 38..54
FT /evidence="ECO:0000250|UniProtKB:Q9NJP7"
SQ SEQUENCE 56 AA; 6032 MW; 70953032042F85BD CRC64;
MSRLFTLVLI VLAMNVMMAI ISDPVVEAVG CEECPMHCKG KMAKPTCDDG VCNCNV