ID   KAX99_BUTOS             Reviewed;          58 AA.
AC   B8XH33;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 2.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Potassium channel toxin alpha-KTx 9.9 {ECO:0000305};
DE   AltName: Full=Toxin Tx549 {ECO:0000312|EMBL:ACJ23142.1};
DE   Flags: Precursor; Fragment;
OS   Buthus occitanus israelis (Common yellow scorpion) (Buthus israelis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Buthus.
OX   NCBI_TaxID=539894;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Zilberberg N., Kozminsky-Atias A.;
RT   "Buthus occitanus israelis scorpion toxin.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potassium channel inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000250|UniProtKB:Q9NJP7}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 09 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACJ23142.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FJ360822; ACJ23142.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; B8XH33; -.
DR   SMR; B8XH33; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          <1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..30
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000428963"
FT   PEPTIDE         31..58
FT                   /note="Potassium channel toxin alpha-KTx 9.9"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000428964"
FT   DISULFID        33..49
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT   DISULFID        36..54
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT   DISULFID        40..56
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT   NON_TER         1
SQ   SEQUENCE   58 AA;  6307 MW;  E8BC6260046485AE CRC64;
     KKTSRLFTLV LIVLAMNVMM AIISDPVVEA VGCEECPMHC KGKMAKPTCY DGVCNCNV