ID   KAX9A_MESEU             Reviewed;          28 AA.
AC   P86398;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Potassium channel toxin alpha-KTx 9.10 {ECO:0000305};
DE   AltName: Full=Toxin MeuKTx-5 {ECO:0000303|Ref.1};
OS   Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34648;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RA   Zhu S.Y., Gao B.;
RT   "Characterization of a new alpha-potassium channel toxin from the
RT   Mesobuthus eupeus venom.";
RL   Submitted (NOV-2009) to UniProtKB.
CC   -!- FUNCTION: Blocks Shaker potassium channels. {ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC       beta-sheet by disulfide bonds (CSalpha/beta).
CC       {ECO:0000250|UniProtKB:Q9NJP7}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 09 subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P86398; -.
DR   SMR; P86398; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR008911; Toxin_alpha-KTx_8/9.
DR   Pfam; PF05453; Toxin_6; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..28
FT                   /note="Potassium channel toxin alpha-KTx 9.10"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000401116"
FT   DISULFID        3..19
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT   DISULFID        6..24
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
FT   DISULFID        10..26
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJP7"
SQ   SEQUENCE   28 AA;  2897 MW;  4062AD78A710BE1B CRC64;
     VGCEECPMHC KGKNAVPTCD NGVCNCNA