ID   KAXU1_HOFGE             Reviewed;          66 AA.
AC   P0C8X8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Potassium channel toxin alpha-KTx;
DE   Flags: Precursor;
OS   Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Iuroidea; Hadrurus.
OX   NCBI_TaxID=380989;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=17506894; DOI=10.1186/1471-2164-8-119;
RA   Schwartz E.F., Diego-Garcia E., Rodriguez de la Vega R.C., Possani L.D.;
RT   "Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus
RT   gertschi (Arachnida: Scorpiones).";
RL   BMC Genomics 8:119-119(2007).
CC   -!- FUNCTION: Blocks voltage-gated potassium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. {ECO:0000305}.
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DR   EMBL; EL698898; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0C8X8; -.
DR   SMR; P0C8X8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..65
FT                   /note="Potassium channel toxin alpha-KTx"
FT                   /id="PRO_0000366117"
FT   DISULFID        29..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..64
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   66 AA;  7583 MW;  008374DC1AC6C326 CRC64;
     MNTKVVLIML MITSVILVVE AETLFTANCL DRKDCKKHCK SKGCKEMKCE QIIKPTWRCL
     CIMCSK