ID   KAXU2_HOFGE             Reviewed;          67 AA.
AC   P0C8X9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Potassium channel toxin alpha-KTx;
DE   Flags: Precursor;
OS   Hoffmannihadrurus gertschi (Scorpion) (Hadrurus gertschi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Iuroidea; Hadrurus.
OX   NCBI_TaxID=380989;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], PARTIAL PROTEIN SEQUENCE, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=17506894; DOI=10.1186/1471-2164-8-119;
RA   Schwartz E.F., Diego-Garcia E., Rodriguez de la Vega R.C., Possani L.D.;
RT   "Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus
RT   gertschi (Arachnida: Scorpiones).";
RL   BMC Genomics 8:119-119(2007).
RN   [2]
RP   FUNCTION, AND SYNTHESIS OF 32-67.
RX   PubMed=29483648; DOI=10.1038/s41594-018-0033-9;
RA   Correnti C.E., Gewe M.M., Mehlin C., Bandaranayake A.D., Johnsen W.A.,
RA   Rupert P.B., Brusniak M.Y., Clarke M., Burke S.E., De Van Der Schueren W.,
RA   Pilat K., Turnbaugh S.M., May D., Watson A., Chan M.K., Bahl C.D.,
RA   Olson J.M., Strong R.K.;
RT   "Screening, large-scale production and structure-based classification of
RT   cystine-dense peptides.";
RL   Nat. Struct. Mol. Biol. 25:270-278(2018).
CC   -!- FUNCTION: Blocks Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated
CC       potassium channels. {ECO:0000269|PubMed:29483648}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17506894}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:17506894}.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. {ECO:0000305}.
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DR   EMBL; EL698899; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0C8X9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..31
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000366118"
FT   PEPTIDE         32..67
FT                   /note="Potassium channel toxin alpha-KTx"
FT                   /evidence="ECO:0000305|PubMed:17506894"
FT                   /id="PRO_0000366119"
FT   DISULFID        35..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..64
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  7585 MW;  4A6F26803A1CA3C7 CRC64;
     MKNIAMKTTV VLTILLLSVL TAINADTMKK RSDYCSNDFC FFSCRRDRCA RGDCENGKCV
     CKNCHLN