ID   KAX_ISOMC               Reviewed;          60 AA.
AC   P0CJ24;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Potassium channel toxin ImKTx88;
DE   Flags: Precursor;
OS   Isometrus maculatus (Lesser brown scorpion) (Scorpio maculatus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Isometrus.
OX   NCBI_TaxID=497827;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Venom gland;
RX   PubMed=21194541; DOI=10.1016/j.toxicon.2010.12.015;
RA   Han S., Hu Y., Zhang R., Yi H., Wei J., Wu Y., Cao Z., Li W., He X.;
RT   "ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion
RT   Isometrus maculates.";
RL   Toxicon 57:348-355(2011).
CC   -!- FUNCTION: Recombinant toxin selectively inhibits Kv1.3/KCNA3 potassium
CC       channels with an IC(50) of 91 pM. {ECO:0000269|PubMed:21194541}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CJ24; -.
DR   SMR; P0CJ24; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR   Pfam; PF00451; Toxin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS01138; SCORP_SHORT_TOXIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..60
FT                   /note="Potassium channel toxin ImKTx88"
FT                   /id="PRO_0000405976"
FT   SITE            50
FT                   /note="Basic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   SITE            59
FT                   /note="Aromatic residue of the functional dyad"
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..51
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..58
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   60 AA;  6763 MW;  F2852DA7169D73C5 CRC64;
     MSNFSVFLIA LLFCSVFILS EAQIYTSKEC NGSSECYSHC EGITGKRSGK CINKKCYCYR