ID   KAX_TITME               Reviewed;          34 AA.
AC   P0DQU3;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 1.
DT   03-AUG-2022, entry version 2.
DE   RecName: Full=Potassium channel toxin {ECO:0000305};
OS   Tityus metuendus (Scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=2203750;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=29337221; DOI=10.1016/j.toxicon.2018.01.006;
RA   Batista C.V.F., Martins J.G., Restano-Cassulini R., Coronas F.I.V.,
RA   Zamudio F.Z., Procopio R., Possani L.D.;
RT   "Venom characterization of the Amazonian scorpion Tityus metuendus.";
RL   Toxicon 143:51-58(2018).
CC   -!- FUNCTION: Toxin that blocks voltage-gated potassium channels (Kv).
CC       {ECO:0000250|UniProtKB:P86270}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29337221}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:29337221}.
CC   -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to
CC       antiparallel beta-sheets by disulfide bonds (CS-alpha/beta).
CC       {ECO:0000250|UniProtKB:P86270}.
CC   -!- MASS SPECTROMETRY: Mass=3927.26; Method=Electrospray; Note=Average
CC       mass.; Evidence={ECO:0000269|PubMed:29337221};
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. Alpha-KTx 21 subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   CHAIN           1..34
FT                   /note="Potassium channel toxin"
FT                   /evidence="ECO:0000269|PubMed:29337221"
FT                   /id="PRO_0000455692"
FT   DISULFID        6..25
FT                   /evidence="ECO:0000250|UniProtKB:Q8I0L5"
FT   DISULFID        11..29
FT                   /evidence="ECO:0000250|UniProtKB:Q8I0L5"
FT   DISULFID        15..31
FT                   /evidence="ECO:0000250|UniProtKB:Q8I0L5"
SQ   SEQUENCE   34 AA;  3934 MW;  53D250477529F7F6 CRC64;
     TPFRYCNPRN CAKECQGRGK ETTYCDEVCK CSGW