KAZRA_DANRE
ID KAZRA_DANRE Reviewed; 786 AA.
AC A9C3W3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Kazrin-A;
GN Name=kazna; Synonyms=kaza; ORFNames=si:dkey-159f12.3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SIMILARITY: Belongs to the kazrin family. {ECO:0000305}.
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DR EMBL; CR936926; CAP19584.1; -; Genomic_DNA.
DR EMBL; CT573404; CAP19584.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001121761.1; NM_001128289.1.
DR AlphaFoldDB; A9C3W3; -.
DR SMR; A9C3W3; -.
DR STRING; 7955.ENSDARP00000098625; -.
DR PaxDb; A9C3W3; -.
DR Ensembl; ENSDART00000139787; ENSDARP00000120248; ENSDARG00000076923.
DR GeneID; 100003663; -.
DR KEGG; dre:100003663; -.
DR CTD; 100003663; -.
DR ZFIN; ZDB-GENE-081105-97; kazna.
DR eggNOG; KOG0249; Eukaryota.
DR GeneTree; ENSGT00940000154570; -.
DR HOGENOM; CLU_010768_2_0_1; -.
DR InParanoid; A9C3W3; -.
DR OMA; YKTGRLP; -.
DR OrthoDB; 558442at2759; -.
DR PhylomeDB; A9C3W3; -.
DR PRO; PR:A9C3W3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000076923; Expressed in muscle tissue and 19 other tissues.
DR CDD; cd09567; SAM_kazrin_repeat2; 1.
DR CDD; cd09570; SAM_kazrin_repeat3; 1.
DR Gene3D; 1.10.150.50; -; 3.
DR InterPro; IPR037614; Kazrin.
DR InterPro; IPR037615; Kazrin_SAM_rpt_2.
DR InterPro; IPR037616; Kazrin_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12776; PTHR12776; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SSF47769; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..786
FT /note="Kazrin-A"
FT /id="PRO_0000322456"
FT DOMAIN 457..522
FT /note="SAM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 535..599
FT /note="SAM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 623..686
FT /note="SAM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 44..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..270
FT /evidence="ECO:0000255"
FT COMPBIAS 50..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 88931 MW; 1BFBABFE62BB3977 CRC64;
MMEENKQLAQ RIDGAIQCAK QDVANLRAEL TATGHRLAEL GELEEPGEPQ EHQQQQQQQN
HQDAPVQRQK ALTELGQKGD VASQETSLDK VLLHEEVLRL QEEVSVLKQV REMLNRELEE
TGGGCSVELM SVSQLRVQLT QKEQELDRAK EALQAMKTDR KRLRLERTDL VNQMQQLYTT
LESREEQLRD FIRNYEQHRK ESEDAVRVLA REKDLLEREK WDLRRQTKEA TEHAGALRSA
LDLKESRIKE LEAELTMAKQ SLATLTKDVP KRHSLAMPTE TVVNGNQEWA MHAELPLTAA
IRQSQQNLYH SIDRQVLKAS PCVCDGDGIS MMSSAAARIS PCHSKQASVM SDASVMEGER
SSTPSDSPRH RTHSLCNSLE DLEEQRRRKK KERMGLGSLS RVFGRGKQRK SMDPTLFDDS
DSLSSPARLS VSLSECEEQL DRLQQVELAR SAPMCRWRAG TVQAWLEVIM AMPMYMRACA
DNVKSGKVLL VLTDEDLGNV LGISNSMHRR KLRLAIEDYR DAEAGHGLSK AAELDHHWVA
QAWLTDVGLP QYSQFFHTHL VDGRLLSTLT RADLEKHLHV SKKAHQNSLL LGIQLLHTLN
FDKEILQSRR SECENQNTDP AVWTCQRIIK WIKEIDLKEF ADNLQTSGVH GAVMVLDPSF
RSDTMATALC IPSNKHMVRH HLSEEMKALV SAARAGLEQE VEPLGTPPTL HRQSSLSSSS
PSCHDDQQSL RRVKQQLGLS PKNLTARNIS HQSRSGSFPR NGLQEVSLQR ERCPVRHFSA
AELTNV
