KAZRN_HUMAN
ID KAZRN_HUMAN Reviewed; 775 AA.
AC Q674X7; B0QYQ0; B1AJZ1; B1AK78; Q5TGF1; Q674X4; Q674X6; Q6ZUD1; Q8IYN7;
AC Q8N409; Q9UIL2; Q9UPX4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Kazrin;
GN Name=KAZN {ECO:0000312|HGNC:HGNC:29173};
GN Synonyms=C1orf196 {ECO:0000312|HGNC:HGNC:29173}, KAZ, KIAA1026;
GN ORFNames=HRIHFB2003;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH PPL.
RC TISSUE=Spinal ganglion;
RX PubMed=15337775; DOI=10.1083/jcb.200312123;
RA Groot K.R., Sevilla L.M., Nishi K., DiColandrea T., Watt F.M.;
RT "Kazrin, a novel periplakin-interacting protein associated with desmosomes
RT and the keratinocyte plasma membrane.";
RL J. Cell Biol. 166:653-659(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-775 (ISOFORM 4), AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Fetal brain;
RX PubMed=9853615; DOI=10.1038/4315;
RA Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.;
RT "Selection system for genes encoding nuclear-targeted proteins.";
RL Nat. Biotechnol. 16:1338-1342(1998).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 536-775 (ISOFORM 1), AND VARIANT
RP THR-706.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352 AND SER-387, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Component of the cornified envelope of keratinocytes. May be
CC involved in the interplay between adherens junctions and desmosomes.
CC The function in the nucleus is not known.
CC {ECO:0000269|PubMed:15337775}.
CC -!- SUBUNIT: Isoform 2, isoform 3 and isoform 4 interact with PPL N-
CC terminus.
CC -!- INTERACTION:
CC Q674X7; P51114: FXR1; NbExp=2; IntAct=EBI-949239, EBI-713291;
CC Q674X7; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-949239, EBI-741037;
CC Q674X7; Q92574: TSC1; NbExp=2; IntAct=EBI-949239, EBI-1047085;
CC Q674X7-2; Q03989: ARID5A; NbExp=3; IntAct=EBI-12024294, EBI-948603;
CC Q674X7-2; Q5SYC1: CLVS2; NbExp=3; IntAct=EBI-12024294, EBI-12357161;
CC Q674X7-2; Q92997: DVL3; NbExp=3; IntAct=EBI-12024294, EBI-739789;
CC Q674X7-2; P25791-3: LMO2; NbExp=3; IntAct=EBI-12024294, EBI-11959475;
CC Q674X7-2; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-12024294, EBI-1216080;
CC Q674X7-2; P25786: PSMA1; NbExp=6; IntAct=EBI-12024294, EBI-359352;
CC Q674X7-2; Q8IZW8: TNS4; NbExp=3; IntAct=EBI-12024294, EBI-7543499;
CC Q674X7-2; Q99757: TXN2; NbExp=3; IntAct=EBI-12024294, EBI-2932492;
CC Q674X7-2; O75604: USP2; NbExp=3; IntAct=EBI-12024294, EBI-743272;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Cell junction, desmosome.
CC Nucleus. Note=Observed at the apical plasma membrane of keratinocytes.
CC Partially colocalizes with PPL and DP at desmosomes, and with PP at the
CC interdesmosomal plasma membrane. Colocalizes with cortical actin-based
CC membrane structures.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cell junction, desmosome.
CC Nucleus. Note=Observed at the apical plasma membrane of keratinocytes.
CC Partially colocalizes with PPL and DP at desmosomes, and with PP at the
CC interdesmosomal plasma membrane. Colocalizes with cortical actin-based
CC membrane structures.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Cell junction, desmosome.
CC Nucleus. Note=Observed at the apical plasma membrane of keratinocytes.
CC Partially colocalizes with PPL and DP at desmosomes, and with PP at the
CC interdesmosomal plasma membrane. Colocalizes with cortical actin-based
CC membrane structures.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q674X7-1; Sequence=Displayed;
CC Name=2; Synonyms=A;
CC IsoId=Q674X7-2; Sequence=VSP_031901, VSP_031903;
CC Name=3; Synonyms=B;
CC IsoId=Q674X7-3; Sequence=VSP_031899, VSP_031901, VSP_031903;
CC Name=4; Synonyms=C, D;
CC IsoId=Q674X7-4; Sequence=VSP_031898, VSP_031901, VSP_031903;
CC Name=5;
CC IsoId=Q674X7-5; Sequence=VSP_031900, VSP_031902;
CC -!- TISSUE SPECIFICITY: Isoform 2, isoform 3 and isoform 4 are expressed in
CC several cell lines including keratinocytes and bladder and epidermoid
CC carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are
CC expressed in hair follicle and interfollicular epidermis (at protein
CC level). {ECO:0000269|PubMed:15337775}.
CC -!- SIMILARITY: Belongs to the kazrin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH36877.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence has been translated in the reverse direction.; Evidence={ECO:0000305};
CC Sequence=AAI01638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI13622.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA82978.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA88115.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC86294.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY505119; AAS86434.1; -; mRNA.
DR EMBL; AY505120; AAS86435.1; -; mRNA.
DR EMBL; AY505121; AAS86436.1; -; mRNA.
DR EMBL; AY505122; AAS86437.1; -; mRNA.
DR EMBL; AB028949; BAA82978.1; ALT_INIT; mRNA.
DR EMBL; AL034395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL391215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471167; EAW51704.1; -; Genomic_DNA.
DR EMBL; BC035501; AAH35501.3; -; mRNA.
DR EMBL; BC036877; AAH36877.1; ALT_SEQ; mRNA.
DR EMBL; BC101637; AAI01638.1; ALT_INIT; mRNA.
DR EMBL; BC113621; AAI13622.1; ALT_INIT; mRNA.
DR EMBL; AB015329; BAA88115.1; ALT_FRAME; mRNA.
DR EMBL; AK125794; BAC86294.1; ALT_INIT; mRNA.
DR CCDS; CCDS152.2; -. [Q674X7-1]
DR CCDS; CCDS30604.1; -. [Q674X7-3]
DR CCDS; CCDS41267.1; -. [Q674X7-2]
DR CCDS; CCDS41268.1; -. [Q674X7-4]
DR RefSeq; NP_001017999.1; NM_001017999.2. [Q674X7-4]
DR RefSeq; NP_001018000.1; NM_001018000.3. [Q674X7-3]
DR RefSeq; NP_001018001.1; NM_001018001.2. [Q674X7-4]
DR RefSeq; NP_056024.1; NM_015209.2. [Q674X7-2]
DR RefSeq; NP_963922.2; NM_201628.2. [Q674X7-1]
DR RefSeq; XP_016856260.1; XM_017000771.1. [Q674X7-2]
DR AlphaFoldDB; Q674X7; -.
DR SMR; Q674X7; -.
DR BioGRID; 116858; 27.
DR IntAct; Q674X7; 16.
DR MINT; Q674X7; -.
DR STRING; 9606.ENSP00000365198; -.
DR GlyGen; Q674X7; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q674X7; -.
DR PhosphoSitePlus; Q674X7; -.
DR BioMuta; HGNC:32336; -.
DR BioMuta; KAZN; -.
DR DMDM; 172044653; -.
DR EPD; Q674X7; -.
DR jPOST; Q674X7; -.
DR MassIVE; Q674X7; -.
DR MaxQB; Q674X7; -.
DR PaxDb; Q674X7; -.
DR PeptideAtlas; Q674X7; -.
DR PRIDE; Q674X7; -.
DR ProteomicsDB; 3001; -.
DR ProteomicsDB; 65976; -. [Q674X7-1]
DR ProteomicsDB; 65977; -. [Q674X7-2]
DR ProteomicsDB; 65978; -. [Q674X7-3]
DR ProteomicsDB; 65979; -. [Q674X7-4]
DR ProteomicsDB; 65980; -. [Q674X7-5]
DR Antibodypedia; 28740; 109 antibodies from 19 providers.
DR DNASU; 23254; -.
DR Ensembl; ENST00000361144.9; ENSP00000354727.5; ENSG00000189337.17. [Q674X7-3]
DR Ensembl; ENST00000376030.7; ENSP00000365198.2; ENSG00000189337.17. [Q674X7-1]
DR Ensembl; ENST00000400797.3; ENSP00000383601.3; ENSG00000189337.17. [Q674X7-4]
DR Ensembl; ENST00000400798.6; ENSP00000383602.2; ENSG00000189337.17. [Q674X7-4]
DR Ensembl; ENST00000503743.5; ENSP00000426015.1; ENSG00000189337.17. [Q674X7-2]
DR GeneID; 23254; -.
DR KEGG; hsa:23254; -.
DR MANE-Select; ENST00000376030.7; ENSP00000365198.2; NM_201628.3; NP_963922.2.
DR UCSC; uc001avm.5; human. [Q674X7-1]
DR CTD; 23254; -.
DR DisGeNET; 23254; -.
DR GeneCards; KAZN; -.
DR HGNC; HGNC:29173; KAZN.
DR HPA; ENSG00000189337; Tissue enhanced (lymphoid).
DR MIM; 618301; gene.
DR neXtProt; NX_Q674X7; -.
DR OpenTargets; ENSG00000189337; -.
DR VEuPathDB; HostDB:ENSG00000189337; -.
DR eggNOG; KOG0249; Eukaryota.
DR GeneTree; ENSGT00940000154570; -.
DR HOGENOM; CLU_010768_2_0_1; -.
DR InParanoid; Q674X7; -.
DR OrthoDB; 558442at2759; -.
DR PhylomeDB; Q674X7; -.
DR TreeFam; TF331216; -.
DR TreeFam; TF343181; -.
DR PathwayCommons; Q674X7; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q674X7; -.
DR BioGRID-ORCS; 23254; 10 hits in 1079 CRISPR screens.
DR ChiTaRS; KAZN; human.
DR GenomeRNAi; 23254; -.
DR Pharos; Q674X7; Tbio.
DR PRO; PR:Q674X7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q674X7; protein.
DR Bgee; ENSG00000189337; Expressed in cerebellar vermis and 197 other tissues.
DR ExpressionAtlas; Q674X7; baseline and differential.
DR Genevisible; Q674X7; HS.
DR GO; GO:0001533; C:cornified envelope; IDA:MGI.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0030057; C:desmosome; IDA:MGI.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR CDD; cd09564; SAM_kazrin_repeat1; 1.
DR CDD; cd09567; SAM_kazrin_repeat2; 1.
DR CDD; cd09570; SAM_kazrin_repeat3; 1.
DR Gene3D; 1.10.150.50; -; 3.
DR InterPro; IPR037614; Kazrin.
DR InterPro; IPR037613; Kazrin_SAM_rpt_1.
DR InterPro; IPR037615; Kazrin_SAM_rpt_2.
DR InterPro; IPR037616; Kazrin_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12776; PTHR12776; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SSF47769; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell junction; Coiled coil; Cytoplasm; Cytoskeleton;
KW Keratinization; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..775
FT /note="Kazrin"
FT /id="PRO_0000322453"
FT DOMAIN 446..511
FT /note="SAM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 524..588
FT /note="SAM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 612..679
FT /note="SAM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 38..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..333
FT /note="Interaction with PPL"
FT /evidence="ECO:0000269|PubMed:15337775"
FT REGION 290..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 74..256
FT /evidence="ECO:0000255"
FT COMPBIAS 311..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q69ZS8"
FT MOD_RES 387
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..94
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15337775,
FT ECO:0000303|PubMed:9853615"
FT /id="VSP_031898"
FT VAR_SEQ 1..75
FT /note="MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGA
FT AASASAAGDSAATNMENPQLGAQ -> MRAADSGSWERVRQLAAQGEPAPSCGAGAGPA
FT RPPGPAACEQCVDAAGPGDRPRAGVPRVRADGDCSQP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15337775,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031899"
FT VAR_SEQ 350..421
FT /note="GDSPGPVQKNLHNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSL
FT DPGLFDDSDSQCSPTRQSLS -> VRPAAAGPGPLGPAQKLQGRGWRGEAILAVSSRPP
FT REHSGECISCSVLSFCKKRWMWGEKGMRPVCSLCPGG (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10470851"
FT /id="VSP_031900"
FT VAR_SEQ 408..422
FT /note="DSDSQCSPTRQSLSL -> GTAPDYYIEEDADW (in isoform 2,
FT isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15337775,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:9853615"
FT /id="VSP_031901"
FT VAR_SEQ 422..775
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10470851"
FT /id="VSP_031902"
FT VAR_SEQ 423..775
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15337775,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:9853615"
FT /id="VSP_031903"
FT VARIANT 706
FT /note="A -> T (in dbSNP:rs10803354)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_060168"
FT VARIANT 763
FT /note="R -> C (in dbSNP:rs12048768)"
FT /id="VAR_060169"
FT CONFLICT 348..349
FT /note="CN -> S (in Ref. 6; BAA88115)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 775 AA; 86351 MW; 7A13B7F262C79294 CRC64;
MMEDNKQLAL RIDGAVQSAS QEVTNLRAEL TATNRRLAEL SGGGGPGPGP GAAASASAAG
DSAATNMENP QLGAQVLLRE EVSRLQEEVH LLRQMKEMLA KDLEESQGGK SSEVLSATEL
RVQLAQKEQE LARAKEALQA MKADRKRLKG EKTDLVSQMQ QLYATLESRE EQLRDFIRNY
EQHRKESEDA VKALAKEKDL LEREKWELRR QAKEATDHAT ALRSQLDLKD NRMKELEAEL
AMAKQSLATL TKDVPKRHSL AMPGETVLNG NQEWVVQADL PLTAAIRQSQ QTLYHSHPPH
PADRQAVRVS PCHSRQPSVI SDASAAEGDR SSTPSDINSP RHRTHSLCNG DSPGPVQKNL
HNPIVQSLED LEDQKRKKKK EKMGFGSISR VFARGKQRKS LDPGLFDDSD SQCSPTRQSL
SLSEGEEQMD RLQQVELVRT TPMSHWKAGT VQAWLEVVMA MPMYVKACTE NVKSGKVLLS
LSDEDLQLGL GVCSSLHRRK LRLAIEDYRD AEAGRSLSKA AELDHHWVAK AWLNDIGLSQ
YSQAFQNHLV DGRMLNSLMK RDLEKHLNVS KKFHQVSILL GIELLYQVNF SREALQERRA
RCETQNIDPV VWTNQRVLKW VRDIDLKEYA DNLTNSGVHG AVLVLEPTFN AEAMATALGI
PSGKHILRRH LAEEMSAVFH PANSTGIREA ERFGTPPGRA SSVTRAGKEE NSSGLKYKAG
RLPLGKIGRG FSSKDPDFHD DYGSLQNEDC GDDDPQSRLE QCRLEGYNSL EVTNV
