KAZRN_RAT
ID KAZRN_RAT Reviewed; 780 AA.
AC Q5FWS6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Kazrin;
GN Name=Kazn; Synonyms=Kaz;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the cornified envelope of keratinocytes. May be
CC involved in the interplay between adherens junctions and desmosomes.
CC The function in the nucleus is not known (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5FWS6-1; Sequence=Displayed;
CC Name=2; Synonyms=C;
CC IsoId=Q5FWS6-2; Sequence=VSP_031908, VSP_031909, VSP_031910;
CC -!- SIMILARITY: Belongs to the kazrin family. {ECO:0000305}.
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DR EMBL; AABR03041495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03041163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089223; AAH89223.1; -; mRNA.
DR RefSeq; NP_001014092.2; NM_001014070.2.
DR AlphaFoldDB; Q5FWS6; -.
DR SMR; Q5FWS6; -.
DR STRING; 10116.ENSRNOP00000019447; -.
DR iPTMnet; Q5FWS6; -.
DR PhosphoSitePlus; Q5FWS6; -.
DR PaxDb; Q5FWS6; -.
DR PRIDE; Q5FWS6; -.
DR Ensembl; ENSRNOT00000019447; ENSRNOP00000019447; ENSRNOG00000014322. [Q5FWS6-1]
DR GeneID; 313672; -.
DR KEGG; rno:313672; -.
DR UCSC; RGD:1359147; rat. [Q5FWS6-1]
DR CTD; 23254; -.
DR RGD; 1359147; Kazn.
DR eggNOG; KOG0249; Eukaryota.
DR GeneTree; ENSGT00940000154570; -.
DR HOGENOM; CLU_010768_2_0_1; -.
DR InParanoid; Q5FWS6; -.
DR OrthoDB; 558442at2759; -.
DR PhylomeDB; Q5FWS6; -.
DR TreeFam; TF331216; -.
DR Reactome; R-RNO-6809371; Formation of the cornified envelope.
DR PRO; PR:Q5FWS6; -.
DR Proteomes; UP000002494; Chromosome 5.
DR GO; GO:0001533; C:cornified envelope; ISO:RGD.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030057; C:desmosome; ISO:RGD.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR CDD; cd09564; SAM_kazrin_repeat1; 1.
DR CDD; cd09567; SAM_kazrin_repeat2; 1.
DR CDD; cd09570; SAM_kazrin_repeat3; 1.
DR Gene3D; 1.10.150.50; -; 3.
DR InterPro; IPR037614; Kazrin.
DR InterPro; IPR037613; Kazrin_SAM_rpt_1.
DR InterPro; IPR037615; Kazrin_SAM_rpt_2.
DR InterPro; IPR037616; Kazrin_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12776; PTHR12776; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SSF47769; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell junction; Coiled coil; Cytoplasm; Cytoskeleton;
KW Keratinization; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..780
FT /note="Kazrin"
FT /id="PRO_0000322455"
FT DOMAIN 451..516
FT /note="SAM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 529..593
FT /note="SAM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 617..684
FT /note="SAM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT REGION 295..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..261
FT /evidence="ECO:0000255"
FT COMPBIAS 316..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 357
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q674X7"
FT MOD_RES 372
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q69ZS8"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q674X7"
FT VAR_SEQ 1..99
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031908"
FT VAR_SEQ 413..426
FT /note="DSDSQCSPTRHSLS -> GTAPDYYIEEDADW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031909"
FT VAR_SEQ 427..780
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031910"
SQ SEQUENCE 780 AA; 86974 MW; B2F40D2283FE4CE5 CRC64;
MMEDNKQLAL RIDGAVQSAS QEVTNLRAEL TATNRRLAEL SGGGGGPGSG PGAATSASAA
AVTVADSAVA TMENHQHGAQ VLLREEVVQL QEEVHLLRQM KEMLAKDLEE SQGGKCSEVL
SATELRVQLV QKEQELARAR EALQAMKADR KRLKGEKTDL VSQMQQLYAT LESREEQLRD
FIRNYEQHRK ESEDAVKALA KEKDLLEREK WELRRQAKEA TDHAAALRSQ LDLKDNRMKE
LEAELAMAKQ SLATLTKDVP KRHSLAMPGE TVLNGNQEWV VQADLPLTAA IRQSQQTLYH
SHPPHPADRQ AVRVSPCHSR QPSVISDASA AEGDRSSTPS DINSPRHRTH SLCNGDSPGP
VQKSLHNPIV QSLEDLEDQK RKKKKEKMGF GSISRVFARG KQRKSLDPGL FDDSDSQCSP
TRHSLSLSEG EEQMDRLQHV ELVRTTPMSH WKAGTVQAWL EVVMAMPMYV KACAENVKSG
KVLLSLSDED LELGLGVCSS LHRRKLRLAI EDYRDAEAGR SLSKAADLDH HWVAKAWLND
IGLSQYSQAF QNHLVDGRML NSLMKRDLEK HLNVSKKFHQ VSILLGIELL YQVNFSREAL
QERRARCETQ NTDPVVWTNQ RVLKWVRDID LKEYADNLTN SGVHGAVLVL EPTFNAEAMA
TALGIPSGKH ILRRHLAEEM STVFHPANST GIRESERFGT PPGRASSITR AGKEDGSSNS
KYRTGRLPLG KIGRGFSSKE PDYYDDYGSL ENEDCGDDDL QGRPEQCRLE EYSSLEVTNV
