KBAA_BACSU
ID KBAA_BACSU Reviewed; 198 AA.
AC P16449;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=KinB-signaling pathway activation protein;
GN Name=kbaA; Synonyms=ybaM, ybxC; OrderedLocusNames=BSU01560;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=168 / JH642;
RX PubMed=8576055; DOI=10.1128/jb.178.4.1178-1186.1996;
RA Dartois V., Djavakhishvili T., Hoch J.A.;
RT "Identification of a membrane protein involved in activation of the KinB
RT pathway to sporulation in Bacillus subtilis.";
RL J. Bacteriol. 178:1178-1186(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969501; DOI=10.1099/13500872-142-11-3039;
RA Yasumoto K., Liu H., Jeong S.M., Ohashi Y., Kakinuma S., Tanaka K.,
RA Kawamura F., Yoshikawa H., Takahashi H.;
RT "Sequence analysis of a 50 kb region between spo0H and rrnH on the Bacillus
RT subtilis chromosome.";
RL Microbiology 142:3039-3046(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91.
RC STRAIN=168;
RX PubMed=2517635; DOI=10.1099/00221287-135-12-3431;
RA Yon J.R., Sammons R.L., Smith D.A.;
RT "Cloning and sequencing of the gerD gene of Bacillus subtilis.";
RL J. Gen. Microbiol. 135:3431-3445(1989).
CC -!- FUNCTION: Involved in the activation of the KinB signaling pathway of
CC sporulation. {ECO:0000269|PubMed:8576055}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8576055};
CC Multi-pass membrane protein {ECO:0000305|PubMed:8576055}.
CC -!- DISRUPTION PHENOTYPE: No effect on sporulation as single mutant, but
CC when associated with deletion of kinA, sporulation efficiency is
CC significantly decreased. {ECO:0000269|PubMed:8576055}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA22469.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U23797; AAC44000.1; -; Genomic_DNA.
DR EMBL; D64126; BAA10996.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB11932.1; -; Genomic_DNA.
DR EMBL; M27259; AAA22469.2; ALT_INIT; Genomic_DNA.
DR PIR; JC6024; JC6024.
DR RefSeq; NP_388037.1; NC_000964.3.
DR RefSeq; WP_004399693.1; NZ_JNCM01000029.1.
DR AlphaFoldDB; P16449; -.
DR STRING; 224308.BSU01560; -.
DR PaxDb; P16449; -.
DR PRIDE; P16449; -.
DR EnsemblBacteria; CAB11932; CAB11932; BSU_01560.
DR GeneID; 938913; -.
DR KEGG; bsu:BSU01560; -.
DR PATRIC; fig|224308.179.peg.160; -.
DR eggNOG; COG2194; Bacteria.
DR OMA; DLVYFRY; -.
DR BioCyc; BSUB:BSU01560-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045881; P:positive regulation of sporulation resulting in formation of a cellular spore; IGI:UniProtKB.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR024164; KinB-signalling_activ.
DR Pfam; PF14089; KbaA; 1.
DR PIRSF; PIRSF029886; KBAA; 1.
DR SMART; SM01251; KbaA; 1.
PE 4: Predicted;
KW Cell membrane; Membrane; Reference proteome; Sporulation; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..198
FT /note="KinB-signaling pathway activation protein"
FT /id="PRO_0000084297"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 198 AA; 22775 MW; 24917B51F38E0ACD CRC64;
MKSRGLVRFF FSILAVGALI TSIVGFALKW GEYRGLFLTF EAGQIFSVLF WFIGVGMIFS
VISQMGFFVF LTVHRFALEI LRSSSLWNLL QLFFILFVAF DLMYVRFLFF GESGESLAGY
AWLPVFLLIF GVITAYIKQK QSSKKTFVSS LFLMVVITAL EWFPALRVND EDWLYLMLFP
LMACNAFQLL MLPKFAAK
