KBAZ_ECOLI
ID KBAZ_ECOLI Reviewed; 426 AA.
AC P0C8K0; P42903; Q2M977;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit KbaZ;
GN Name=kbaZ; Synonyms=agaZ, yhaX; OrderedLocusNames=b3132, JW3101;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP DISCUSSION OF SEQUENCE.
RX PubMed=8932697; DOI=10.1099/13500872-142-2-231;
RA Reizer J., Ramseier T.M., Reizer A., Charbit A., Saier M.H. Jr.;
RT "Novel phosphotransferase genes revealed by bacterial genome sequencing: a
RT gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in
RT Escherichia coli.";
RL Microbiology 142:231-250(1996).
RN [4]
RP FUNCTION AS A TAGBP ALDOLASE COMPONENT, AND COMPLEX WITH KBAY.
RX PubMed=11976750; DOI=10.1007/s00203-002-0406-6;
RA Brinkkoetter A., Shakeri-Garakani A., Lengeler J.W.;
RT "Two class II D-tagatose-bisphosphate aldolases from enteric bacteria.";
RL Arch. Microbiol. 177:410-419(2002).
CC -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase KbaYZ
CC that is required for full activity and stability of the Y subunit.
CC Could have a chaperone-like function for the proper and stable folding
CC of KbaY. When expressed alone, KbaZ does not show any aldolase
CC activity. {ECO:0000269|PubMed:11976750}.
CC -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC phosphate: step 2/2.
CC -!- SUBUNIT: Forms a complex with KbaY.
CC -!- MISCELLANEOUS: In contrast to E.coli strains C and EC3132, K-12 strains
CC cannot grow on N-acetylgalactosamine and D-galactosamine, because they
CC carry a deletion and thus lack active PTS systems specific for these
CC compounds. Therefore, KbaYZ in K-12 strains is not involved in the
CC degradation of these compounds.
CC -!- SIMILARITY: Belongs to the GatZ/KbaZ family. KbaZ subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be a tagatose 6-phosphate kinase.
CC {ECO:0000305|PubMed:8932697}.
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DR EMBL; U18997; AAA57935.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76166.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77179.1; -; Genomic_DNA.
DR PIR; H65102; H65102.
DR RefSeq; NP_417601.1; NC_000913.3.
DR RefSeq; WP_000681920.1; NZ_LN832404.1.
DR AlphaFoldDB; P0C8K0; -.
DR SMR; P0C8K0; -.
DR BioGRID; 4263374; 9.
DR ComplexPortal; CPX-6022; KbaYZ tagatose-1,6-bisphosphate aldolase complex.
DR DIP; DIP-9075N; -.
DR IntAct; P0C8K0; 7.
DR STRING; 511145.b3132; -.
DR jPOST; P0C8K0; -.
DR PaxDb; P0C8K0; -.
DR PRIDE; P0C8K0; -.
DR DNASU; 947637; -.
DR EnsemblBacteria; AAC76166; AAC76166; b3132.
DR EnsemblBacteria; BAE77179; BAE77179; BAE77179.
DR GeneID; 947637; -.
DR KEGG; ecj:JW3101; -.
DR KEGG; eco:b3132; -.
DR PATRIC; fig|1411691.4.peg.3599; -.
DR EchoBASE; EB2616; -.
DR eggNOG; COG4573; Bacteria.
DR HOGENOM; CLU_053334_0_0_6; -.
DR InParanoid; P0C8K0; -.
DR OMA; QRHFSYS; -.
DR PhylomeDB; P0C8K0; -.
DR BioCyc; EcoCyc:G7631-MON; -.
DR BioCyc; MetaCyc:G7631-MON; -.
DR SABIO-RK; P0C8K0; -.
DR UniPathway; UPA00704; UER00716.
DR PRO; PR:P0C8K0; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:1902494; C:catalytic complex; IC:ComplexPortal.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008047; F:enzyme activator activity; IMP:EcoCyc.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IC:ComplexPortal.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_01295; Tagatose_aldol_KbaZ; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR012062; GatZ/KbaZ-like.
DR InterPro; IPR023435; TagBP_ald_KbaZ.
DR Pfam; PF08013; GatZ_KbaZ-like; 1.
DR PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..426
FT /note="D-tagatose-1,6-bisphosphate aldolase subunit KbaZ"
FT /id="PRO_0000064493"
SQ SEQUENCE 426 AA; 47192 MW; FC97956E662EA939 CRC64;
MKHLTEMVRQ HKAGKTNGIY AVCSAHPLVL EAAIRYASAN QTPLLIEATS NQVDQFGGYT
GMTPADFRGF VCQLADSLNF PQDALILGGD HLGPNRWQNL PAAQAMANAD DLIKSYVAAG
FKKIHLDCSM SCQDDPIPLT DDIVAERAAR LAKVAEETCL EHFGEADLEY VIGTEVPVPG
GAHETLSELA VTTPDAARAT LEAHRHAFEK QGLNAIWPRI IALVVQPGVE FDHTNVIDYQ
PAKASALSQM VENYETLIFE AHSTDYQTPQ SLRQLVIDHF AILKVGPALT FALREALFSL
AAIEEELVPA KACSGLRQVL EDVMLDRPEY WQSHYHGDGN ARRLARGYSY SDRVRYYWPD
SQIDDAFAHL VRNLADSPIP LPLISQYLPL QYVKVRSGEL QPTPRELIIN HIQDILAQYH
TACEGQ
