KBP_CHICK
ID KBP_CHICK Reviewed; 594 AA.
AC Q5ZIL9;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=KIF-binding protein;
DE AltName: Full=KIF1-binding protein;
GN Name=Kifbp; Synonyms=kbp; ORFNames=RCJMB04_25c4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Required for organization of axonal microtubules, and axonal
CC outgrowth and maintenance during peripheral and central nervous system
CC development. {ECO:0000250|UniProtKB:Q96EK5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q96EK5}.
CC -!- SIMILARITY: Belongs to the KIF-binding protein family. {ECO:0000305}.
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DR EMBL; AJ720765; CAG32424.1; -; mRNA.
DR RefSeq; NP_001007945.1; NM_001007944.1.
DR AlphaFoldDB; Q5ZIL9; -.
DR SMR; Q5ZIL9; -.
DR STRING; 9031.ENSGALP00000006597; -.
DR PaxDb; Q5ZIL9; -.
DR Ensembl; ENSGALT00000006608; ENSGALP00000006597; ENSGALG00000004156.
DR GeneID; 423694; -.
DR KEGG; gga:423694; -.
DR CTD; 423694; -.
DR VEuPathDB; HostDB:geneid_423694; -.
DR eggNOG; ENOG502QPZT; Eukaryota.
DR GeneTree; ENSGT00390000013819; -.
DR HOGENOM; CLU_019859_1_0_1; -.
DR InParanoid; Q5ZIL9; -.
DR OMA; ICRECWY; -.
DR OrthoDB; 1516717at2759; -.
DR PhylomeDB; Q5ZIL9; -.
DR TreeFam; TF324211; -.
DR PRO; PR:Q5ZIL9; -.
DR Proteomes; UP000000539; Chromosome 6.
DR Bgee; ENSGALG00000004156; Expressed in spermatid and 13 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; ISS:UniProtKB.
DR GO; GO:1990535; P:neuron projection maintenance; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR022083; KBP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR46321; PTHR46321; 1.
DR Pfam; PF12309; KBP_C; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW Neurogenesis; Reference proteome.
FT CHAIN 1..594
FT /note="KIF-binding protein"
FT /id="PRO_0000050793"
SQ SEQUENCE 594 AA; 69081 MW; 7E14BD21231BB763 CRC64;
MAAAGGGWAA ACEKFRSART LSAVESRKDP ETEPYRSKYS ARALLQEVKQ QLSAAEDCGE
ARLLAVRRAV LEYELGVNHT DTEELSAGEE HLQRCTQLLE PHRLSRDCVS LYIQAQNNLG
ILWSERDEIK TAQTYLESAE ALYNQYMKED GNPPLDPSEH FMAEEEKLTD QERSKRFEKA
YTHTLYYLAQ VYQHLEMIEK AAQYCHTTLK RQLEYCGYYP VEWALNAATL SQYYLSKQCF
MESRHCLAAA SVIFSQAGQV PSTEDNETEQ DQQDLRQRKA EIARCWIKYC LNLLQSARKL
LEDNIGELDP DRQLELKAQR KKEEDEKENG RKKAVLFGTS DICDSVLAME EKVSSVYPLD
FQEAREIFLV GQNYVQEAKE FFQVDGYVTD HIEIVQDHSA LFKVLAFFEE DYERRCKMHK
RRIDMLEPIY ADLNPQYYLL ISRQLQFELA DTYYEMMDLK VAIGNRLEEL DSHTIKKINS
LAQLAIKYYE LFLDSLRNPD KVFPEELEED VLRPAMVAKF HIARLYGKLI TSDSKKQLEN
MQTSLEYYTF LVDYCEKHPD AVRAVETELE LSKEMVGLLP TRMERLRAKL CPFI