ID   KBP_DANRE               Reviewed;         631 AA.
AC   A8WE67;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=KIF-binding protein;
DE   AltName: Full=KIF1-binding protein;
GN   Name=kifbp; Synonyms=kbp, kif1bp;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=18192286; DOI=10.1242/dev.012377;
RA   Lyons D.A., Naylor S.G., Mercurio S., Dominguez C., Talbot W.S.;
RT   "KBP is essential for axonal structure, outgrowth and maintenance in
RT   zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen
RT   syndrome.";
RL   Development 135:599-608(2008).
CC   -!- FUNCTION: Required for organization of axonal microtubules, and axonal
CC       outgrowth and maintenance during peripheral and central nervous system
CC       development. {ECO:0000269|PubMed:18192286}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q96EK5}.
CC   -!- TISSUE SPECIFICITY: At 30 hpf, primarily expressed in central and
CC       peripheral neurons. {ECO:0000269|PubMed:18192286}.
CC   -!- SIMILARITY: Belongs to the KIF-binding protein family. {ECO:0000305}.
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DR   EMBL; EU234534; ABW89743.1; -; mRNA.
DR   AlphaFoldDB; A8WE67; -.
DR   SMR; A8WE67; -.
DR   STRING; 7955.ENSDARP00000083675; -.
DR   PaxDb; A8WE67; -.
DR   PeptideAtlas; A8WE67; -.
DR   PRIDE; A8WE67; -.
DR   ZFIN; ZDB-GENE-070117-1989; kifbp.
DR   eggNOG; ENOG502QPZT; Eukaryota.
DR   InParanoid; A8WE67; -.
DR   PRO; PR:A8WE67; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IMP:ZFIN.
DR   GO; GO:0048929; P:efferent axon development in posterior lateral line nerve; IMP:ZFIN.
DR   GO; GO:0048484; P:enteric nervous system development; IMP:ZFIN.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:ZFIN.
DR   GO; GO:0006839; P:mitochondrial transport; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IGI:ZFIN.
DR   GO; GO:1990535; P:neuron projection maintenance; IMP:ZFIN.
DR   InterPro; IPR022083; KBP.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46321; PTHR46321; 1.
DR   Pfam; PF12309; KBP_C; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW   Neurogenesis; Reference proteome.
FT   CHAIN           1..631
FT                   /note="KIF-binding protein"
FT                   /id="PRO_0000334518"
FT   REGION          60..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..78
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   631 AA;  72816 MW;  ABE771CF3152C7D4 CRC64;
     MAANNSIEWR AVCEKFRLAQ ELSEIESKKD PENNPFRSKY KARDLLKEIH CSLKKIEIEE
     QGEAGDEADC ESSQTADGEP EDGFEKTFTG DSAAGLRAAR LAVLQYHLGV NHIETEELSA
     GELHLMVCMK LIDKCTTTRE NVSLFIHVRN QLGILWAGRD EIEKAQGFLE IAETMYLVYM
     KEDGQPPLDL QDFFVPEGEE LSQQEKIRRF EMAYTHTLYY LAQVYKNLQQ YERAAQYCHS
     TLQRQLEYKQ FAPLEWAINA ATLSQYYITK TRYMEARHCL AAASVIANLA GEIPSEAAAK
     ESEAESEKRE ELLQKRAEIA RCWIKYCLNL LQDAKKLLED NIGELDLDRQ DELKRARRNE
     EEEKEKGRKS AILFGSSDTF DSICSLEEKV SSMLPLEFEE ARSIFLVGQS YVTQAKEYFA
     MDGHVTDHIE ILQDHSALFK VLAFFEEDLE RRCKMHKRRV DMLEPICKDL NAQYYLLICR
     QLQFELAETY YEMMDLKLAV ADKLDQPDVH TIKKFNHLCS SSMKYYQMFL DSTRSPEGKF
     PEKLEDDLLR PALVAKFRVA RLHSKLISSN LATQMENLSL SLESYNFVVQ YCEENPEAKN
     AVETELELSM EMVSLLPLKI NRIRSTLASS K